Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester.
Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester.
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DOI：
10.1016/j.fertnstert.2021.04.031
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发表时间：
2021-09
影响因子：
6.7
通讯作者：
Dhillo WS
中科院分区：
文献类型：
--
作者：
Abbara A;Al-Memar M;Phylactou M;Kyriacou C;Eng PC;Nadir R;Izzi-Engbeaya C;Clarke SA;Mills EG;Daniels E;Huo L;Pacuszka E;Yang L;Patel B;Tan T;Bech P;Comninos AN;Fourie H;Kelsey TW;Bourne T;Dhillo WS
比较Kisspeptin和β人绒毛膜促性腺激素（βhCG）单独使用和联合使用作为妊娠早期流产生物标志物的性能。前瞻性、巢式病例对照研究。联合王国伦敦夏洛特女王医院第三中心。流产的成年女性（n = 95，173份样本）和健康妊娠的女性（n = 265，557份样本）。受试者在孕早期接受了一系列超声扫描和血液采样，以测量血浆kisspeptin和βhCG水平。血浆Kisspeptin和βhCG水平区分妊娠合并流产与未流产的健康妊娠的能力流产妇女的循环kisspeptin和βhCG的妊娠调整水平分别比健康妊娠妇女低79%和70%。妊娠早期识别流产的受试者工作特征曲线下面积，kisspeptin为0.874（95%置信区间[CI] 0.844-0.904），βhCG为0.859（95% CI 0.820-0.899），两种标志物之和为0.916（95% CI 0.886-0.946）。随着妊娠时间的延长，kisspeptin在识别流产方面的表现有所改善，而βhCG的表现则有所恶化。结合kisspeptin、βhCG和胎龄的决策矩阵预测流产的准确率为83%至87%。血浆kisspeptin是一种有前途的流产生物标志物，为单独βhCG提供了额外的价值，特别是在孕早期的后几周。
To compare the performance of kisspeptin and beta human chorionic gonadotropin (βhCG), both alone and in combination, as biomarkers for miscarriage throughout the first trimester. Prospective, nested case-control study. Tertiary Centre, Queen Charlotte Hospital, London, United Kingdom. Adult women who had miscarriages (n = 95, 173 samples) and women with healthy pregnancies (n = 265, 557 samples). The participants underwent serial ultrasound scans and blood sampling for measurement of plasma kisspeptin and βhCG levels during the first trimester. The ability of plasma kisspeptin and βhCG levels to distinguish pregnancies complicated by miscarriage from healthy pregnancies unaffected by miscarriage. Gestation-adjusted levels of circulating kisspeptin and βhCG were lower in samples from women with miscarriages than in women with healthy pregnancies by 79% and 70%, respectively. The area under the receiver-operating characteristic curve for identifying miscarriage during the first trimester was 0.874 (95% confidence interval [CI] 0.844–0.904) for kisspeptin, 0.859 (95% CI 0.820–0.899) for βhCG, and 0.916 (95% CI 0.886–0.946) for the sum of the two markers. The performance of kisspeptin in identifying miscarriage improved with increasing length of gestation, whereas that of βhCG worsened. A decision matrix incorporating kisspeptin, βhCG, and gestational age had 83% to 87% accuracy for the prediction of miscarriage. Plasma kisspeptin is a promising biomarker for miscarriage and provides additional value to βhCG alone, especially during later gestational weeks of the first trimester.
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影响因子：
9.8
作者：
Ilekis JV;Tsilou E;Fisher S;Abrahams VM;Soares MJ;Cross JC;Zamudio S;Illsley NP;Myatt L;Colvis C;Costantine MM;Haas DM;Sadovsky Y;Weiner C;Rytting E;Bidwell G
通讯作者：
Bidwell G
DOI：
10.1530/joe-12-0091
发表时间：
2012-07
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Cartwright JE;Williams PJ
通讯作者：
Williams PJ
影响因子：
4.8
作者：
Calder, Michele;Chan, Yee-Ming;Babwah, Andy V.
通讯作者：
Babwah, Andy V.
影响因子：
3.7
作者：
Francis VA;Abera AB;Matjila M;Millar RP;Katz AA
通讯作者：
Katz AA
影响因子：
5.2
作者：
Ciaramella V;Della Corte CM;Ciardiello F;Morgillo F
通讯作者：
Morgillo F