Longitudinal Evaluation of Cerebral Growth Across Childhood in Boys and Girls With Autism Spectrum Disorder.
Longitudinal Evaluation of Cerebral Growth Across Childhood in Boys and Girls With Autism Spectrum Disorder.
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自闭症谱系障碍儿童期大脑发育的纵向评估
DOI：
10.1016/j.biopsych.2020.10.014
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发表时间：
2021-09-01
影响因子：
10.6
通讯作者：
Nordahl CW
中科院分区：
文献类型：
--
作者：
Lee JK;Andrews DS;Ozonoff S;Solomon M;Rogers S;Amaral DG;Nordahl CW
患有自闭症谱系障碍（ASD）的儿童经常报告大脑过度生长，而成人则没有。这表明早期大脑过度生长之后是脑容量的正常化。然而，这一概念是基于易受抽样偏差影响的横断面研究。例如，患有不成比例巨脑畸形（ASD-DM）的自闭症个体，这是一个智力残疾率更高、脑容量更大的亚群，在青少年和成人的研究中可能代表性不足。此外，现有的研究以男性为主，因此限制了对女性自闭症患者大脑发育的了解。采用混合效应模型，对273名男孩（199名ASD）和156名女孩（95名ASD）在多达四个时间点（平均年龄：38、50、64、137个月）和多达三个时间点（平均年龄：39、53、65个月）扫描的纵向样本进行了脑总（TCV）、灰质（GM）和白质（WM）体积的生长和TCV的GM比例进行了检测。在患有ASD的男孩中，ASD- dm亚组的大脑过度生长主要是由GM的增加驱动的，并且在整个儿童期持续存在，没有体积回归或正常化的证据。在患有ASD的女孩中，脑容量与TD女孩相似，但在儿童早期，GM和WM的生长轨迹较慢。与TD对照组相比，自闭症男孩和女孩的GM / TCV比例随年龄下降的速度较慢。纵向证据并不支持早期大脑过度生长会导致体积退化的观点，至少从童年早期到晚期是如此。
Cerebral overgrowth is frequently reported in children but not adults with autism spectrum disorder (ASD). This suggests that early cerebral over-growth is followed by normalization of cerebral volumes. However, this notion is predicated upon cross-sectional research that is vulnerable to sampling bias. For example, autistic individuals with disproportionate megalencephaly (ASD-DM), a subgroup with higher rates of intellectual disability and larger cerebral volumes, may be under-represented in studies of adolescents and adults. Furthermore, extant studies have cohorts that are predominately male thus limiting knowledge of cerebral growth in females with ASD. Growth of total cerebral (TCV), gray (GM) and white (WM) matter volume, and GM proportion of TCV was examined in a longitudinal sample comprising 273 boys (199 ASD) scanned at up to four timepoints (Mean ages: 38, 50, 64, 137 months) and 156 girls (95 ASD) scanned at up to three timepoints (Mean ages: 39, 53, 65 months) using mixed effects modeling. In boys with ASD, cerebral overgrowth in the ASD-DM subgroup was predominately driven by increases in GM and persisted throughout childhood without evidence of volumetric regression or normalization. In girls with ASD, cerebral volumes were similar to TD girls, but growth trajectories of GM and WM were slower throughout early childhood. Proportion of GM to TCV declined with age a slower rate in autistic boys and girls relative to TD controls. Longitudinal evidence does not support the notion that early brain overgrowth is followed by volumetric regression, at least from early to late childhood.
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影响因子：
9.9
作者：
Aylward, EH;Minshew, NJ;Singh, N
通讯作者：
Singh, N
影响因子：
4.7
作者：
Amaral, David G.;Li, Deana;Nordahl, Christine Wu
通讯作者：
Nordahl, Christine Wu
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.9
作者：
Fombonne, E;Rogé, B;Frémolle, J
通讯作者：
Frémolle, J
影响因子：
2.9
作者：
Avino, Thomas A.;Hutsler, Jeffrey J.
通讯作者：
Hutsler, Jeffrey J.