Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma.
Comprehensive Analysis of the Expression and Prognosis Value of Chromobox Family Members in Clear Cell Renal Cell Carcinoma.
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Chromobox家族成员在透明细胞肾细胞癌中的表达及预后价值综合分析
DOI：
10.3389/fonc.2021.700528
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发表时间：
2021
影响因子：
4.7
通讯作者：
Peng F
中科院分区：
文献类型：
--
作者：
Zhu Y;Pu Z;Li Z;Lin Y;Li N;Peng F
Clear cell renal cell carcinoma (ccRCC) accounts for 80% of all renal cancers and has a poor prognosis. Chromobox (CBX) family protein expression has been reported in a variety of human malignancies, but the roles of CBXs in ccRCC remain unclear. In this study, by using ONCOMINE, UALCAN, GEPIA, Kaplan-Meier Plotter, cBioPortal, and TIMER, we found the transcriptional levels of CBX3 and CBX4 in ccRCC tissues were significantly higher than those in normal kidney tissues, whereas the transcriptional levels of CBX1, CBX5, CBX6, and CBX7 were significantly reduced in ccRCC tissues. The promoters of CBX2, CBX3, CBX4, CBX5, CBX6, CBX7, and CBX8 were hypermethylated, whereas the CBX1 promoter was hypomethylated in ccRCC. The expression of CBX1, CBX3, CBX4, CBX5, CBX6, and CBX7 was significantly associated with clinicopathological parameters in ccRCC patients. ccRCC patients with high expression levels of CBX3, CBX4, and CBX8 and low expression levels of CBX1, CBX5, CBX6, and CBX7 showed a strong association with poor overall survival. Genetic alterations in CBXs were correlated with poor overall survival and disease-free survival in patients with ccRCC. Moreover, we found significant associations between the expression of CBXs and infiltration of immune cells (B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells). Our results provide novel insights into the development of CBX-based biomarkers and therapeutic targets for ccRCC.
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影响因子：
8.8
作者：
Clermont, P-L;Sun, L.;Crea, F.;Thu, K. L.;Zhang, A.;Parolia, A.;Lam, W. L.;Helgason, C. D.
通讯作者：
Helgason, C. D.
影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
LNCRNA linc00998通过CBX3介导的C-MET/AKT/MTOR轴抑制恶性神经胶质瘤表型。
影响因子：
9
作者：
Cai H;Yu Y;Ni X;Li C;Hu Y;Wang J;Chen F;Xi S;Chen Z
通讯作者：
Chen Z
影响因子：
4
作者：
Gong L;Tang Y;Jiang L;Tang W;Luo S
通讯作者：
Luo S
影响因子：
12.3
作者：
Li B;Severson E;Pignon JC;Zhao H;Li T;Novak J;Jiang P;Shen H;Aster JC;Rodig S;Signoretti S;Liu JS;Liu XS
通讯作者：
Liu XS