Accuracy of a Novel Non-Invasive technology based EZSCAN system for the diagnosis of diabetes mellitus in Chinese.
Accuracy of a Novel Non-Invasive technology based EZSCAN system for the diagnosis of diabetes mellitus in Chinese.
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基于新型无创技术的 EZSCAN 系统诊断中国糖尿病的准确性。
DOI：
10.1186/1758-5996-3-36
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发表时间：
2011-12-22
影响因子：
4.8
通讯作者：
Wang JG
中科院分区：
文献类型：
--
作者：
Sheng CS;Zeng WF;Huang QF;Deslypere JP;Li Y;Wang JG
最近开发了一种基于离子电渗技术的新的简单技术（EQUIPCAN，Impeto Medical，巴黎，法国）用于筛选糖尿病。在本研究中，我们调查了该系统的准确性，为中国糖尿病的诊断。我们在糖尿病和非糖尿病受试者中进行了EQUIPCAN测试。EQUIPCAN测量前额、手和脚的电化学电导（EC），并得出糖尿病指数，数值范围为0至100。糖尿病定义为空腹时血糖浓度至少为7 mmol/l或葡萄糖负荷后2小时血糖浓度至少为11.1 mmol/l，或使用降糖药物。195名研究参与者（51%男性，平均年龄52岁）包括75名糖尿病患者（81%使用降糖药物）和120名非糖尿病受试者。糖尿病患者的手（44 vs. 61）和脚（51 vs. 69）位置的EC（微西门子，μSi）显著（P < 0.001）较低，但前额（15 vs. 17，P = 0.39）不显著。当糖尿病指数为40（由制造商建议）作为阈值时，诊断糖尿病的敏感性和特异性分别为85%和64%。在80例接受口服葡萄糖耐量试验的患者中，手足EC和糖尿病指数与负荷后2小时血糖和血清糖化血红蛋白均显著相关（P < 0.001）。依西比康对糖尿病的筛查具有一定的敏感性和特异性。
A new simple technique based on iontophoresis technology (EZSCAN, Impeto Medical, Paris, France) has recently been developed for the screening of diabetes. In the present study, we investigated the accuracy of this system for the diagnosis of diabetes mellitus in Chinese. We performed the EZSCAN test in diabetic and non-diabetic subjects. EZSCAN measures electrochemical conductance (EC) at forehead, hands and feet, and derives a diabetes index with a value ranging from 0 to 100. Diabetes mellitus was defined as a plasma glucose concentration of at least 7 mmol/l at fasting or 11.1 mmol/l at 2 hours after glucose load, or as the use of antidiabetic drugs. The 195 study participants (51% men, mean age 52 years) included 75 diabetic patients (use of antidiabetic drugs 81%) and 120 non-diabetic subjects. EC (micro Siemens, μSi) was significantly (P < 0.001) lower in diabetic patients at the hands (44 vs. 61) and feet (51 vs. 69) locations, but not at the forehead (15 vs. 17, P = 0.39). When a diabetes index of 40 (suggested by the manufacturer) was used as the threshold, the sensitivity and specificity for the diagnosis of diabetes mellitus was 85% and 64%, respectively. In 80 patients who underwent an oral glucose tolerance test, EC at hands and feet and the diabetes index were significantly (P < 0.001) associated with both 2-hour post-load plasma glucose and serum glycosylated haemoglobin. EZSCAN might be useful in screening diabetes mellitus with reasonable sensitivity and specificity.
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