Sertoli cells--immunological sentinels of spermatogenesis.
Sertoli cells--immunological sentinels of spermatogenesis.
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DOI：
10.1016/j.semcdb.2014.02.011
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发表时间：
2014-06
影响因子：
7.3
通讯作者：
Dufour, Jannette M.
中科院分区：
文献类型：
--
作者：
Kaur, Gurvinder;Thompson, Lea Ann;Dufour, Jannette M.
睾丸生殖细胞，在中心耐受建立后出现，表达新的细胞表面和细胞内蛋白，可被宿主免疫系统识别为“外来抗原”。然而，正常情况下，这些生殖细胞不会引起自身反应性免疫反应。本文的重点是回顾血睾丸屏障(BTB)/支持细胞（SC）屏障以及SC调节免疫反应的能力对保护自身抗原生殖细胞至关重要的证据。在正常睾丸中，BTB/SC屏障通过限制免疫系统的进入和隔离这些“新抗原”来保护大多数自身抗原生殖细胞。SCs还通过表达多种免疫调节因子来调节睾丸免疫细胞（诱导调节性免疫细胞），从而为非隔离的自身抗原生殖细胞的生存创造一个最佳的局部耐受性环境。总的来说，BTB/SC屏障创建的堡垒以及免疫反应的调节对精子发生和物种生存的完成至关重要。
Testicular germ cells, which appear after the establishment of central tolerance, express novel cell surface and intracellular proteins that can be recognized as ‘foreign antigens’ by the host’s immune system. However, normally these germ cells do not evoke an auto-reactive immune response. The focus of this manuscript is to review the evidence that the Blood-Testis-Barrier (BTB)/Sertoli cell (SC) barrier along with the SCs ability to modulate the immune response is vital for protecting auto-antigenic germ cells. In normal testis, the BTB/SC barrier protects the majority of the auto-antigenic germ cells by limiting access by the immune system and sequestering these ‘new antigens’. SCs also modulate testis immune cells (induce regulatory immune cells) by expressing several immunoregulatory factors, thereby creating a local tolerogenic environment optimal for survival of nonsequesetred auto-antigenic germ cells. Collectively, the fortress created by the BTB/SC barrier along with modulation of the immune response is pivotal for completion of spermatogenesis and species survival.
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影响因子：
4.1
作者：
Bailey, R;Griswold, MD
通讯作者：
Griswold, MD
影响因子：
--
作者：
CHIQUOINE, A
通讯作者：
CHIQUOINE, A
影响因子：
3.8
作者：
Herrid, Muren;Vignarajan, Soma;Hill, Jonathan R.
通讯作者：
Hill, Jonathan R.
影响因子：
4
作者：
Hirst, CE;Buzza, MS;Bird, PI
通讯作者：
Bird, PI
影响因子：
3.6
作者：
Dal Secco, Valentina;Riccioli, Anna;Filippini, Antonio
通讯作者：
Filippini, Antonio