Nicotinic receptor modulation to treat alcohol and drug dependence.
Nicotinic receptor modulation to treat alcohol and drug dependence.
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DOI：
10.3389/fnins.2014.00426
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发表时间：
2014
影响因子：
4.3
通讯作者：
Bell RL
中科院分区：
文献类型：
--
作者：
Rahman S;Engleman EA;Bell RL
酒精和药物依赖是世界范围内严重的公共卫生问题。在美国和世界其他地区，酒精和药物依赖的流行率很高。鉴于目前药物疗法治疗这些疾病的疗效有限，开发替代药物疗法的研究仍在继续。迄今为止的临床前和临床证据表明，脑尼古丁乙酰胆碱受体（nAChR）是开发治疗酒精和药物依赖药物的重要药理学靶点。nAChR是配体门控离子通道的超家族，并且在整个脑中表达，鉴定了12个神经元nAChR亚基（α2-α10和β2-β4）。在这里，我们回顾了临床前和临床证据，涉及一些nAChR配体，针对不同的nAChR亚型的酒精和尼古丁成瘾。重要的配体包括野靛碱，洛贝林，美加明，伐尼克兰，sazetidine A和其他靶向α4β2* nAChR亚型作为脑烟碱胆碱能系统的小分子调节剂也进行了讨论。总之，临床前和临床数据都支持基于nAChR的配体作为治疗酒精和药物依赖的有前途的治疗剂。
Alcohol and drug dependence are serious public health problems worldwide. The prevalence of alcohol and drug dependence in the United States and other parts of the world is significant. Given the limitations in the efficacy of current pharmacotherapies to treat these disorders, research in developing alternative pharmacotherapies continues. Preclinical and clinical evidence thus far has indicated that brain nicotinic acetylcholine receptors (nAChRs) are important pharmacological targets for the development of medications to treat alcohol and drug dependence. The nAChRs are a super family of ligand gated ion channels, and are expressed throughout the brain with twelve neuronal nAChR subunits (α2–α10 and β2–β4) identified. Here, we review preclinical and clinical evidence involving a number of nAChR ligands that target different nAChR subtypes in alcohol and nicotine addiction. The important ligands include cytisine, lobeline, mecamylamine, varenicline, sazetidine A and others that target α4β2* nAChR subtypes as small molecule modulators of the brain nicotinic cholinergic system are also discussed. Taken together, both preclinical and clinical data exist that support nAChR–based ligands as promising therapeutic agents for the treatment of alcohol and drug dependence.
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DOI：
10.2174/187152710790966597
发表时间：
2010-03
期刊：
CNS & neurological disorders drug targets
影响因子：
--
作者：
Chatterjee S;Bartlett SE
通讯作者：
Bartlett SE
DOI：
10.1016/b978-0-12-420118-7.00013-5
发表时间：
2014
期刊：
Advances in pharmacology (San Diego, Calif.)
影响因子：
--
作者：
Crooks, Peter A;Bardo, Michael T;Dwoskin, Linda P
通讯作者：
Dwoskin, Linda P
影响因子：
3.6
作者：
Bell, Richard L.;Sable, Helen J. K.;Colombo, Giancarlo;Hyytia, Petri;Rodd, Zachary A.;Lumeng, Lawrence
通讯作者：
Lumeng, Lawrence
影响因子：
7.3
作者：
Clarke, PBS;Reuben, M
通讯作者：
Reuben, M
DOI：
10.1124/jpet.108.145292
发表时间：
2009-02-01
影响因子：
3.5
作者：
Buccafusco, Jerry J.;Beach, J. Warren;Terry, Alvin V., Jr.
通讯作者：
Terry, Alvin V., Jr.