Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders.
Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders.
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DOI：
10.2174/187152710790966597
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Bartlett SE
中科院分区：
文献类型：
--
作者：
Chatterjee S;Bartlett SE
酒精使用障碍（AUDs）是复杂的，开发有效的治疗方法将需要结合新的药物和认知行为治疗方法。流行病学研究表明，饮酒和吸烟之间存在高度相关性，酗酒者的吸烟率高达80%，而普通人群的吸烟率约为30%。临床前和临床数据均提供证据表明，尼古丁给药可增加酒精摄入量，非特异性尼古丁受体拮抗剂可减少酒精介导的行为。由于尼古丁与神经元烟碱乙酰胆碱受体（nAChR）系统特异性相互作用，这表明nAChR在酒精的行为效应中发挥重要作用。在这篇综述中，我们讨论了nAChRs治疗AUDs的重要性，并认为使用FDA批准的nAChR配体，如伐尼克兰和美加明，批准作为戒烟辅助剂可能被证明是有价值的AUDs治疗。我们还强调了将有效的药物与行为疗法相结合治疗酒精依赖者的重要性。
Alcohol use disorders (AUDs) are complex and developing effective treatments will require the combination of novel medications and cognitive behavioral therapy approaches. Epidemiological studies have shown there is a high correlation between alcohol consumption and tobacco use, and the prevalence of smoking in alcoholics is as high as 80% compared to about 30% for the general population. Both preclinical and clinical data provide evidence that nicotine administration increases alcohol intake and non-specific nicotinic receptor antagonists reduce alcohol-mediated behaviors. As nicotine interacts specifically with the neuronal nicotinic acetylcholine receptor (nAChR) system, this suggests that nAChRs play an important role in the behavioral effects of alcohol. In this review, we discuss the importance of nAChRs for the treatment of AUDs and argue that the use of FDA approved nAChR ligands, such as varenicline and mecamylamine, approved as smoking cessation aids may prove to be valuable treatments for AUDs. We also address the importance of combining effective medications with behavioral therapy for the treatment of alcohol dependent individuals.
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