The Upsides and Downsides of Organelle Interconnectivity.

The Upsides and Downsides of Organelle Interconnectivity.
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DOI:
10.1016/j.cell.2017.02.030
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发表时间:
2017-03-23
期刊:
影响因子:
64.5
通讯作者:
Nyström T
Nyström T
中科院分区:
生物学1区
文献类型:
--
作者:
Gottschling DE;Nyström T

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相互连接和反馈控制是生物系统的标志。这包括细胞器之间的通信,使它们能够发挥作用并适应不断变化的细胞环境。虽然所有通信的具体机制仍然不透明,但解开细胞器网络的布线对于理解生物系统如何构建以及为什么它们可能崩溃至关重要,就像衰老一样。对细胞器间通讯的所有途径的全面了解仍然缺乏,但重要的主题开始出现,主要是在芽殖酵母中。这些路线在这里审查的背景下,子系统蛋白质和复杂适应系统理论。
Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in inter-organelle communication is still lacking but important themes are beginning to emerge, primarily in budding yeast. These routes are reviewed here in the context of sub-system proteostasis and Complex Adaptive Systems theory.
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