Reduced capacity but spared precision and maintenance of working memory representations in schizophrenia.
Reduced capacity but spared precision and maintenance of working memory representations in schizophrenia.
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DOI：
10.1001/archgenpsychiatry.2010.65
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发表时间：
2010-06
影响因子：
--
通讯作者：
Luck, Steven J.
中科院分区：
文献类型：
--
作者：
Gold, James M.;Hahn, Britta;Zhang, Wei Wei;Robinson, Benjamin M.;Kappenman, Emily S.;Beck, Valerie M.;Luck, Steven J.
工作记忆缺陷被认为是精神分裂症的一个核心特征。最近的几篇综合论文提供了这种认知缺陷起源的机械计算和神经生物学模型。为了检验这些模型的预测，我们使用了一种来自基础科学文献的新实验范式，从而可以确定精神分裂症患者是否表现出：1)工作记忆存储容量的缺陷，2)工作记忆表征的准确性缺陷，以及3)这些缺陷随着保持间隔的增加而扩大。病例对照设计。所有受试者都进行了一项颜色工作记忆测试，在1或4秒的延迟后，他们被要求回忆3或4个项目。所有的研究对象还接受了智力和矩阵电池的标准测量。三级保健研究门诊诊所。共有31名经DSM IV诊断为精神分裂症或分裂情感性障碍的临床稳定患者和26名健康志愿者参与。两组在年龄、性别和种族分布上相似。我们检查了两个结果测量：1)工作记忆中存储的项目数量，以及2)工作记忆表征的精度。患者在工作记忆中存储的项目数量明显减少。在工作记忆表征的精确度上，患者与对照组并无不同。在能力或精确度方面没有延迟相关的损伤放大的证据。患者没有表现出基于当前疾病的神经生物学模型所预测的不精确或延迟依赖的损伤放大类型。这些模型需要修改，以解释患者能够在工作记忆中存储的项目数量的纯粹减少。
Working memory deficits are considered a core feature of schizophrenia. Several recent integrative papers have offered mechanistic computational and neurobiological models of the origins of this cognitive deficit. To test predictions of these models using a new experimental paradigm from the basic science literature that makes it possible to determine whether patients with schizophrenia show: 1) deficits in working memory storage capacity, 2) deficits in the precision of working memory representations, and 3) an amplification of these deficits as the retention interval increases. Case control design. All subjects performed a color working memory test where they were asked to recall 3 or 4 items after a 1 or 4 second delay. All subjects also received a standard measure of intelligence and the MATRICS battery. A tertiary care research outpatient clinic. A total of 31 clinically stable patients with a DSM IV diagnosis of schizophrenia or schizoaffective disorder and 26 healthy volunteers participated. The two groups were similar in age, gender, and ethnicity distributions. We examined two outcome measures: 1) the number of items stored in working memory, and 2) the precision of the working memory representations. Patients showed a clear reduction in the number of items stored in working memory. Patients did not differ from controls in the precision of their working memory representations. There was no evidence of delay-related amplification of impairment in either capacity or precision. Patients do not show the type of imprecision or delay-dependent amplification of impairment that are predicted on the basis of current models of the neurobiology of the illness. The models need to be revised to account for a pure reduction in the number of items that patients are able to store in working memory.
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影响因子：
17.7
作者：
Callicott, JH;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
10.6
作者：
Arion, Dominique;Unger, Travis;Mirnics, Karoly
通讯作者：
Mirnics, Karoly
影响因子：
4.6
作者：
Gold, James M.;Fuller, Rebecca L.;Luck, Steven J.
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Luck, Steven J.
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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