Effects of CT section thickness and reconstruction kernel on emphysema quantification relationship to the magnitude of the CT emphysema index.
Effects of CT section thickness and reconstruction kernel on emphysema quantification relationship to the magnitude of the CT emphysema index.
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DOI：
10.1016/j.acra.2009.08.007
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发表时间：
2010-02
影响因子：
4.8
通讯作者：
Patterson, G. Alexander
中科院分区：
文献类型：
--
作者：
Gierada, David S.;Bierhals, Andrew J.;Choong, Cliff K.;Bartel, Seth T.;Ritter, Jon H.;Das, Nitin A.;Hong, Cheng;Pilgram, Thomas K.;Bae, Kyongtae T.;Whiting, Bruce R.;Woods, Jason C.;Hogg, James C.;Lutey, Barbara A.;Battafarano, Richard J.;Cooper, Joel D.;Meyers, Bryan F.;Patterson, G. Alexander
CT断面厚度和重建核均影响肺气肿的CT测量。进行这项研究是为了评估它们的影响是否与测量的幅度有关。对 21 名代表不同肺气肿严重程度的受试者进行了低辐射剂量多排 CT 扫描。使用 20 种不同的切片厚度和重建内核组合重建图像。肺气肿指数值被确定为衰减低于范围从-960 HU到-890 HU的多个阈值的肺像素的百分比。通过重复测量方差分析和均值与差值的 Bland-Altman 图比较从不同厚度-内核组合获得的指数值，并与切除肺标本子集中的定量组织学（平均线性截距，Lm）相关。切片厚度和重建内核对肺气肿指数的影响显着（p<0.001），并且随着指数阈值的升高而减弱。对于具有中间指数值（10-30%）的受试者，由于改变厚度-内核组合而导致的指数值变化最大，对于具有较低和较高指数值的受试者来说，指数值的变化逐渐变小。无论比较的厚度-内核组合和使用的 HU 阈值如何，该模式都是一致的。每个厚度-内核组合获得的肺气肿指数值与 Lm 之间的相关性范围为 r=0.55–0.68 (p=0.007–0.03)。 CT切片厚度和内核对肺气肿指数值的影响随着肺气肿指数的大小而系统地变化。所有重建技术都提供了与定量组织学的显着相关性。
CT section thickness and reconstruction kernel each influence CT measurements of emphysema. This study was performed to assess whether their effects are related to the magnitude of the measurement. Low-radiation-dose multidetector CT was performed in 21 subjects representing a wide range of emphysema severity. Images were reconstructed using 20 different combinations of section thickness and reconstruction kernel. Emphysema index values were determined as the percentage of lung pixels having attenuation lower than multiple thresholds ranging from −960 HU to −890 HU. The index values obtained from the different thickness-kernel combinations were compared by repeated measures ANOVA and Bland-Altman plots of mean vs. difference, and correlated with quantitative histology (mean linear intercept, Lm) in a subset of resected lung specimens. The effects of section thickness and reconstruction kernel on the emphysema index were significant (p<0.001) and diminished as the index threshold was raised. The changes in index values due to changing the thickness-kernel combination were largest for subjects with intermediate index values (10–30%), and became progressively smaller for those with lower and higher index values. This pattern was consistent regardless of the thickness-kernel combinations compared and the HU threshold used. Correlations between the emphysema index values obtained with each thickness-kernel combination and Lm ranged from r=0.55–0.68 (p=0.007–0.03). The effects of CT section thickness and kernel on emphysema index values varied systematically with the magnitude of the emphysema index. All reconstruction techniques provided significant correlations with quantitative histology.
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影响因子：
2.8
作者：
MITTERMAYER, C;WYBITUL, K;RIEDE, UN
通讯作者：
RIEDE, UN
影响因子：
19.7
作者：
Boedeker, KL;McNitt-Gray, MF;Goldin, JG
通讯作者：
Goldin, JG
影响因子：
9.6
作者：
Chatila, Wissam M.;Hoffman, Eric A.;Criner, Gerard J.
通讯作者：
Criner, Gerard J.
DOI：
10.1164/ajrccm.154.1.8680679
发表时间：
1996-07-01
影响因子：
24.7
作者：
Gevenois, PA;DeVuyst, P;Yernault, JC
通讯作者：
Yernault, JC
影响因子：
10
作者：
Ogawa, E.;Nakano, Y.;Mishima, M.
通讯作者：
Mishima, M.