Potential Theranostic Roles of SLC4 Molecules in Human Diseases.
Potential Theranostic Roles of SLC4 Molecules in Human Diseases.
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DOI：
10.3390/ijms242015166
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发表时间：
2023-10-13
影响因子：
5.6
通讯作者：
Duan X
中科院分区：
文献类型：
--
作者：
Zhong J;Dong J;Ruan W;Duan X
溶质载体家族4（solute carrier family 4，SLC 4）是一种重要的蛋白质，负责跨细胞膜转运各种离子，并介导多种生理功能，如离子转运功能、蛋白质-蛋白质相互作用和分子转导。SLC 4分子的缺陷可能导致多系统疾病，特别是涉及呼吸系统、消化系统、泌尿系统、内分泌系统、造血系统和中枢神经系统。目前，还没有有效的策略来治疗这些疾病。SLC 4蛋白也被发现参与肿瘤的发生和发展，其中一些蛋白在相当多的临床试验中被视为治疗靶点。这表明SLC 4蛋白具有潜在的临床应用前景。鉴于其功能特点，有必要对碳酸氢盐转运蛋白的功能、相关疾病及其病理机制进行综述。本文对SLC 4家族基因突变引起的疾病进行了综述，并简要介绍了这些疾病的临床表现和目前的治疗策略。此外，本文还从生理学和发病机制两个方面阐述了它们的作用，这些作用可能是未来疾病治疗和诊断的靶点，也是药物研发的新方向。
The solute carrier family 4 (SLC4) is an important protein responsible for the transport of various ions across the cell membrane and mediating diverse physiological functions, such as the ion transporting function, protein-to-protein interactions, and molecular transduction. The deficiencies in SLC4 molecules may cause multisystem disease involving, particularly, the respiratory system, digestive, urinary, endocrine, hematopoietic, and central nervous systems. Currently, there are no effective strategies to treat these diseases. SLC4 proteins are also found to contribute to tumorigenesis and development, and some of them are regarded as therapeutic targets in quite a few clinical trials. This indicates that SLC4 proteins have potential clinical prospects. In view of their functional characteristics, there is a critical need to review the specific functions of bicarbonate transporters, their related diseases, and the involved pathological mechanisms. We summarize the diseases caused by the mutations in SLC4 family genes and briefly introduce the clinical manifestations of these diseases as well as the current treatment strategies. Additionally, we illustrate their roles in terms of the physiology and pathogenesis that has been currently researched, which might be the future therapeutic and diagnostic targets of diseases and a new direction for drug research and development.
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阴离子交换器2抑制细胞运动，并在食管鳞状细胞癌中具有预后意义。
影响因子：
--
作者：
Shiozaki A;Hikami S;Ichikawa D;Kosuga T;Shimizu H;Kudou M;Yamazato Y;Kobayashi T;Shoda K;Arita T;Konishi H;Komatsu S;Kubota T;Fujiwara H;Okamoto K;Kishimoto M;Konishi E;Marunaka Y;Otsuji E
通讯作者：
Otsuji E
了解 Na 偶联 SLC4 转运蛋白在肾脏和神经系统中的功能表达：综述
影响因子：
3.3
作者：
Du L;Zahra A;Jia M;Wang Q;Wu J
通讯作者：
Wu J
DOI：
10.1159/000343332
发表时间：
2012
期刊：
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
影响因子：
--
作者：
Lee S;Yang HS;Kim E;Ju EJ;Kwon MH;Dudley RK;Smith Y;Yun CC;Choi I
通讯作者：
Choi I
影响因子：
5.6
作者：
Wu C;Liu X;Sun R;Qin Y;Liu Z;Yang S;Tang T;Zhu Z;Yu D;Liu F
通讯作者：
Liu F
影响因子：
15.9
作者：
Brown, Matthew R.;Holmes, Heather;Matveyenko, Aleksey, V
通讯作者：
Matveyenko, Aleksey, V