Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling.
Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling.
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DOI：
10.1371/journal.pone.0120821
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Iulianella A
中科院分区：
文献类型：
--
作者：
Kurosaka H;Trainor PA;Leroux-Berger M;Iulianella A
颅神经支配大脑与头部和颈部组织之间的感觉和运动信息交换。颅神经来源于两个专门的细胞群，颅神经嵴细胞和外胚层基板细胞。任何一种细胞类型的缺陷都可能导致脑神经发育缺陷。虽然已知有几种信号通路调节颅神经的形成，但我们对颅神经节形态发生过程中神经嵴细胞和基板细胞之间的细胞间信号传导是如何协调的了解甚少。Sonic Hedgehog（Shh）信号传导是调节颅面发育多个方面的一个关键途径，但在颅神经节形成期间，它是否协调颅神经嵴细胞和基板细胞的相互作用仍不清楚。在这项研究中，我们研究了一种新的Patched 1（Ptch 1）功能丧失的小鼠突变体，并表征了Ptch 1在颅神经节发育过程中调节Shh信号的作用。Ptch 1 Wig/ Wig突变体表现出升高的Shh信号与三叉神经和面神经的紊乱一致。重要的是，我们发现增强的Shh信号抑制了颅神经区域的经典Wnt信号。这对颅神经嵴细胞的存活、迁移、基板细胞的发育以及神经嵴与基板之间的整合有重要影响。总的来说，我们的研究结果强调了Shh信号通过经典Wnt信号的交叉调节在脑神经发育中的新颖和关键作用。
Cranial nerves govern sensory and motor information exchange between the brain and tissues of the head and neck. The cranial nerves are derived from two specialized populations of cells, cranial neural crest cells and ectodermal placode cells. Defects in either cell type can result in cranial nerve developmental defects. Although several signaling pathways are known to regulate cranial nerve formation our understanding of how intercellular signaling between neural crest cells and placode cells is coordinated during cranial ganglia morphogenesis is poorly understood. Sonic Hedgehog (Shh) signaling is one key pathway that regulates multiple aspects of craniofacial development, but whether it co-ordinates cranial neural crest cell and placodal cell interactions during cranial ganglia formation remains unclear. In this study we examined a new Patched1 (Ptch1) loss-of-function mouse mutant and characterized the role of Ptch1 in regulating Shh signaling during cranial ganglia development. Ptch1Wig/ Wig mutants exhibit elevated Shh signaling in concert with disorganization of the trigeminal and facial nerves. Importantly, we discovered that enhanced Shh signaling suppressed canonical Wnt signaling in the cranial nerve region. This critically affected the survival and migration of cranial neural crest cells and the development of placodal cells as well as the integration between neural crest and placodes. Collectively, our findings highlight a novel and critical role for Shh signaling in cranial nerve development via the cross regulation of canonical Wnt signaling.
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影响因子：
2.7
作者：
Dude, Carolynn M.;Kuan, C. -Y. Kelly;Bradshaw, James R.;Greene, Nicholas D. E.;Relaix, Frederic;Stark, Michael R.;Baker, Clare V. H.
通讯作者：
Baker, Clare V. H.
DOI：
10.1083/jcb.201402093
发表时间：
2014-07-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kuriyama S;Theveneau E;Benedetto A;Parsons M;Tanaka M;Charras G;Kabla A;Mayor R
通讯作者：
Mayor R
影响因子：
3.6
作者：
Canning CA;Lee L;Luo SX;Graham A;Jones CM
通讯作者：
Jones CM
影响因子：
15.9
作者：
Kurosaka, Hiroshi;Iulianella, Angelo;Trainor, Paul A.
通讯作者：
Trainor, Paul A.
影响因子：
2.7
作者：
Lassiter, Rhonda N. T.;Dude, Carolynn M.;Stark, Michael R.
通讯作者：
Stark, Michael R.