Role and regulation of heme iron acquisition in gram-negative pathogens.
Role and regulation of heme iron acquisition in gram-negative pathogens.
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DOI：
10.3389/fcimb.2013.00055
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发表时间：
2013
影响因子：
5.7
通讯作者：
Runyen-Janecky LJ
中科院分区：
文献类型：
--
作者：
Runyen-Janecky LJ
存在于动物组织和/或细胞中的细菌必须从其宿主获得铁。然而，几乎所有的宿主铁都被螯合在含铁化合物和蛋白质中，其中大部分存在于血红素分子中。因此，细菌病原体（和非致病性共生体）的可能铁源是游离血红素和含血红素的蛋白质。此外，细菌在宿主内的细胞位置（细胞内或细胞外）影响可用于运输的含铁化合物的量和性质。宿主中游离铁水平较低，再加上存在多种不同的血红素来源，导致细菌内出现了广泛的高亲和力铁获取策略。然而，由于过量的铁和血红素对细菌有毒，这些获取系统的表达受到高度调节。在适当的时间在正确的宿主环境中精确表达使得血红素铁获取系统能够促进宿主内细菌病原体的生长。这篇简短的综述将重点介绍这些领域中革兰氏阴性病原体的一些最新发现。
Bacteria that reside in animal tissues and/or cells must acquire iron from their host. However, almost all of the host iron is sequestered in iron-containing compounds and proteins, the majority of which is found within heme molecules. Thus, likely iron sources for bacterial pathogens (and non-pathogenic symbionts) are free heme and heme-containing proteins. Furthermore, the cellular location of the bacterial within the host (intra or extracellular) influences the amount and nature of the iron containing compounds available for transport. The low level of free iron in the host, coupled with the presence of numerous different heme sources, has resulted in a wide range of high-affinity iron acquisition strategies within bacteria. However, since excess iron and heme are toxic to bacteria, expression of these acquisition systems is highly regulated. Precise expression in the correct host environment at the appropriate times enables heme iron acquisitions systems to contribute to the growth of bacterial pathogens within the host. This mini-review will highlight some of the recent findings in these areas for gram-negative pathogens.
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影响因子：
3.1
作者：
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作者：
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