Prenatal oxycodone exposure impairs spatial learning and/or memory in rats.
Prenatal oxycodone exposure impairs spatial learning and/or memory in rats.
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DOI：
10.1016/j.bbr.2010.03.022
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发表时间：
2010-09-01
影响因子：
2.7
通讯作者：
Schrott, Lisa M.
中科院分区：
文献类型：
--
作者：
Davis, Chris P.;Franklin, La'Tonya M.;Johnson, Gabriel S.;Schrott, Lisa M.
最近吸毒人口格局的变化导致处方阿片剂的非医疗使用增加。这些使用者更年轻，更可能是女性，这有可能增加子宫内暴露率。因此，我们开发了一种大鼠模型，模拟处方阿片类药物依赖的妇女怀孕。成年雌性Sprague-Dawley大鼠经口灌胃给予递增剂量的盐酸羟考酮，直至最终剂量为15 mg/kg/天，持续30天，在繁殖和妊娠期间维持该剂量。对照组用水处理。在径向臂迷宫、Morris水迷宫（试验间隔较短和较长）和空间T迷宫中对这些给药母鼠的成年雄性后代进行检测。产前羟考酮暴露导致桡臂迷宫缺陷，其特征在于更多的参考记忆错误，特别是在测试开始时。相比之下，在T型迷宫中，产前羟考酮暴露的大鼠学习任务以及产前水控制。然而，他们有一个适度的赤字保留任务时，收购培训结束后5天进行评估。在Morris水迷宫中，试验间隔影响学习模式。虽然没有赤字时，训练有一个短的试验间隔，当有一个长的试验间隔，产前羟考酮暴露大鼠有较差的收购。在产前羟考酮暴露的大鼠中，空间学习缺陷的特征在于发现的潜伏期增加和到达平台的距离更远。这些数据得到证实的行为搜索策略，这表明减少使用空间策略和增加非空间策略，特别是墙壁拥抱，在产前羟考酮暴露大鼠相比，产前水控制大鼠在第2天的收购。这些结果表明，产前羟考酮暴露一贯损害学习和记忆中的电池的空间任务。
Recent changes in demographic patterns of drug use have resulted in the increased non-medical use of prescription opiates. These users are younger and more likely to be female, which has the potential for increasing rates of in utero exposure. Therefore, we developed a rat model that simulates a prescription opiate-dependent woman who becomes pregnant. Adult female Sprague-Dawley rats were treated for 30 days via oral gavage with ascending doses of oxycodone HCl up to a final dose of 15 mg/kg/day, which was maintained during breeding and gestation. Controls were treated with water. The adult male offspring of these treated dams were tested on the radial arm maze, the Morris water maze (with a short and a long intertrial interval), and a spatial T-maze. Prenatal oxycodone exposure led to a deficit in the radial arm maze characterized by a greater number of reference memory errors, especially in the beginning of testing. In contrast, in the T-maze, prenatal oxycodone-exposed rats learned the task as well as well as the prenatal water controls. However, they had a modest deficit in retention of the task when assessed 5 days after acquisition training ended. For the Morris water maze, the intertrial interval affected the pattern of learning. While there was no deficit when the training had a short intertrial interval, when there was a long intertrial interval, prenatal oxycodone-exposed rats had poorer acquisition. The spatial learning deficit was characterized by and increased latency to find and a greater distance traveled to the platform in the prenatal oxycodone-exposed rats. These data were corroborated by analysis of the behavioral search strategy, which showed a decreased use of spatial strategies and an increase in non-spatial strategies, especially wall-hugging, in prenatal oxycodone-exposed rats as compared to prenatal water control rats on day 2 of acquisition. These results indicate that prenatal oxycodone exposure consistently impairs learning and memory in a battery of spatial tasks.
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影响因子：
5.3
作者：
Malleret, G;Hen, R;Buhot, MC
通讯作者：
Buhot, MC
DOI：
10.1016/0926-6410(96)00013-4
发表时间：
1996-06-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Macphail, EM
通讯作者：
Macphail, EM
影响因子：
2.5
作者：
Che, Y;Sun, HY;Ma, YY
通讯作者：
Ma, YY
影响因子：
2.9
作者：
Hamilton, KL;Harris, AC;Schrott, LM
通讯作者：
Schrott, LM
影响因子：
2.2
作者：
Pulsifer, MB;Radonovich, K;Butz, AM
通讯作者：
Butz, AM