SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion.
SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion.
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SNAIL 1在肿瘤细胞中的作用通过改变GM-CSF分泌影响乳腺癌中的巨噬细胞极化和转移。
DOI：
10.1038/s41389-018-0042-x
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发表时间：
2018-03-29
期刊：
影响因子：
6.2
通讯作者：
Longmore GD
中科院分区：
文献类型：
--
作者：
Brenot A;Knolhoff BL;DeNardo DG;Longmore GD
EMT诱导剂SNAIL 1调节乳腺癌转移，其在人原发性乳腺肿瘤中的表达预测不良结局。在肿瘤进展过程中，SNAIL 1在肿瘤细胞中具有多种作用，可以影响转移。炎症性肿瘤微环境也影响转移，最近SNAIL 1被认为调节细胞因子的分泌，从而影响肿瘤免疫浸润。使用乳腺癌转移的自发遗传模型和同基因原位移植实验，我们表明，在原发性乳腺肿瘤细胞中SNAIL 1的作用是乳腺肿瘤生长和转移所必需的。其部分通过调节乳腺癌细胞产生GM-CSF、IL 1 α、IL-6和TNFα来实现。SNAIL 1依赖性肿瘤细胞分泌组调节原发性肿瘤相关巨噬细胞（TAM）极化。GM-CSF单独调节TAM极化并影响体内乳腺癌转移。这项研究强调了乳腺肿瘤SNAIL 1在癌症进展到转移中的另一个作用-调节原发性乳腺肿瘤的免疫微环境。
The EMT inducer SNAIL1 regulates breast cancer metastasis and its expression in human primary breast tumor predicts for poor outcomes. During tumor progression SNAIL1 has multiple effects in tumor cells that can impact metastasis. An inflammatory tumor microenvironment also impacts metastasis and recently SNAIL1 has been implicated as modulating the secretion of cytokines that can influence the tumor immune infiltrate. Using a spontaneous genetic model of breast cancer metastasis and syngeneic orthotopic transplant experiments we show that the action of SNAIL1 in primary breast tumor cells is required for breast tumor growth and metastasis. It does so, in part, by regulating production of GM-CSF, IL1α, IL-6, and TNFα by breast cancer cells. The SNAIL1-dependent tumor cell secretome modulates the primary tumor-associated macrophage (TAM) polarization. GM-CSF alone modulates TAM polarization and impacts breast cancer metastasis in vivo. This study highlights another role for breast tumor SNAIL1 in cancer progression to metastasis—modulation of the immune microenvironment of primary breast tumors.
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影响因子：
3.7
作者：
Jablonski KA;Amici SA;Webb LM;Ruiz-Rosado Jde D;Popovich PG;Partida-Sanchez S;Guerau-de-Arellano M
通讯作者：
Guerau-de-Arellano M
DOI：
10.1038/nri2528
发表时间：
2009-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
7.2
作者：
Coussens, Lisa M.;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.
影响因子：
11.2
作者：
Movahedi, Kiavash;Laoui, Damya;Van Ginderachter, Jo A.
通讯作者：
Van Ginderachter, Jo A.
影响因子：
50.3
作者：
Moody, SE;Perez, D;Chodosh, LA
通讯作者：
Chodosh, LA