Measuring depression levels in HIV-infected patients as part of routine clinical care using the nine-item Patient Health Questionnaire (PHQ-9).

Measuring depression levels in HIV-infected patients as part of routine clinical care using the nine-item Patient Health Questionnaire (PHQ-9).
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DOI:
10.1080/09540120903483034
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发表时间:
2010-07
期刊:
影响因子:
1.7
通讯作者:
Crane HM
Crane HM
中科院分区:
医学4区
文献类型:
--
作者:
Crane PK;Gibbons LE;Willig JH;Mugavero MJ;Lawrence ST;Schumacher JE;Saag MS;Kitahata MM;Crane HM

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对艾滋病毒感染者抑郁工具的心理测量特性了解甚少。我们使用来自PRIME-MD (PHQ-9)的9项患者健康问卷分析了来自美国两个城市的常规护理患者的大样本数据(n=1467)。PHQ-9具有曲线标度特性,并且沿着仪器测量的抑郁连续体具有不同水平的测量精度。在我们的队列中,量表显示出显著的地板效应和分数在抑郁严重程度水平上的分布。三个项目在种族方面具有差异项目功能(DIF)(非裔美国人与白人);其中两个人在性别方面有DIF,一人在年龄方面有DIF。个人水平的DIF影响最小。非裔美国人和白人平均抑郁程度的差异中有20%是由DIF造成的。虽然PHQ-9的标准分数可能适用于艾滋病毒感染者的个体横断面设置,但这些结果表明,跨群体和跨时间的抑郁症调查可能需要更复杂的分析框架。
Little is known about the psychometric properties of depression instruments among persons infected with HIV. We analyzed data from a large sample of patients in usual care in two US cities (n=1467) using the 9-item Patient Health Questionnaire from the PRIME-MD (the PHQ-9). The PHQ-9 had curvilinear scaling properties and varying levels of measurement precision along the continuum of depression measured by the instrument. In our cohort, the scale showed a prominent floor effect and a distribution of scores across depression severity levels. Three items had differential item functioning (DIF) with respect to race (African-American vs. white); two had DIF with respect to sex, and one had DIF with respect to age. There was minimal individual-level DIF impact. Twenty percent of the difference in mean depression levels between African-Americans and whites was due to DIF. While standard scores for the PHQ-9 may be appropriate for use with individual HIV-infected patients in cross-sectional settings, these results suggest that investigations of depression across groups and within patients across time may require a more sophisticated analytic framework.
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