Current understanding of photophobia, visual networks and headaches.
Current understanding of photophobia, visual networks and headaches.
复制标题
DOI：
10.1177/0333102418784750
复制
发表时间：
2019-11
期刊：
影响因子：
--
通讯作者：
Burstein R
中科院分区：
文献类型：
--
作者：
Noseda R;Copenhagen D;Burstein R
回顾临床和临床前证据，支持从眼睛到大脑皮层的视觉通路在头痛性疾病中恐惧症的发展中的作用。畏光症是一种知之甚少的光诱导现象，出现在各种神经和眼科疾病。多年来，已经提出了多种机制来解释其原因;然而，缺乏研究和缺乏对患者恐惧症的系统评估，使得寻找答案变得非常具有挑战性。在头痛领域，最近在特定视觉网络如何促成偏头痛特征方面取得了重大进展，例如偏头痛患者经常经历的光诱导头痛加剧，亮度感知增加和视觉不适。这些进展提高了我们对这一现象的理解，并指出了锥/杆介导的图像形成和黑视蛋白介导的非图像形成视觉通路对光的异常处理，以及光信号向涉及感觉、自主神经和情绪调节的多个大脑区域的相应转移。畏光的表型是多样的，视觉，三叉神经和自主神经系统的相对贡献可能取决于它出现的疾病。在偏头痛中，恐惧症可能是由视网膜驱动的参与调节稳态的通路的光激活引起的，这使得它与头痛的关联比以前认为的更复杂。
To review clinical and pre-clinical evidence supporting the role of visual pathways, from the eye to the cortex, in the development of photophobia in headache disorders. Photophobia is a poorly understood light-induced phenomenon that emerges in a variety of neurological and ophthalmological conditions. Over the years, multiple mechanisms have been proposed to explain its causes; however, scarce research and lack of systematic assessment of photophobia in patients has made the search for answers quite challenging. In the field of headaches, significant progress has been made recently on how specific visual networks contribute to photophobia features such as light-induced intensification of headache, increased perception of brightness and visual discomfort, which are frequently experienced by migraineurs. Such progress improved our understanding of the phenomenon and points to abnormal processing of light by both cone/rod-mediated image-forming and melanopsin-mediated non-image-forming visual pathways, and the consequential transfer of photic signals to multiple brain regions involved in sensory, autonomic and emotional regulation. Photophobia phenotype is diverse, and the relative contribution of visual, trigeminal and autonomic systems may depend on the disease it emerges from. In migraine, photophobia could result from photic activation of retina-driven pathways involved in the regulation of homeostasis, making its association with headache more complex than previously thought.
登录
查看更多内容
影响因子：
14.5
作者：
Afridi, SK;Matharu, MS;Goadsby, PJ
通讯作者：
Goadsby, PJ
影响因子：
11
作者：
COLESTON, DM;CHRONICLE, E;KENNARD, C
通讯作者：
KENNARD, C
影响因子：
5
作者：
Ahn, Andrew H.;Brennan, K. C.
通讯作者：
Brennan, K. C.
影响因子：
64.8
作者：
Dacey, DM;Liao, HW;Gamlin, PD
通讯作者：
Gamlin, PD
影响因子：
2.7
作者：
Coppola, Gianluca;Pierelli, Francesco;Schoenen, Jean
通讯作者：
Schoenen, Jean