Axial Disease in Psoriatic Arthritis study: defining the clinical and radiographic phenotype of psoriatic spondyloarthritis.
Axial Disease in Psoriatic Arthritis study: defining the clinical and radiographic phenotype of psoriatic spondyloarthritis.
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DOI：
10.1136/annrheumdis-2016-209853
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发表时间：
2017-04
影响因子：
27.4
通讯作者：
McHugh NJ
中科院分区：
文献类型：
--
作者：
Jadon DR;Sengupta R;Nightingale A;Lindsay M;Korendowych E;Robinson G;Jobling A;Shaddick G;Bi J;Winchester R;Giles JT;McHugh NJ
目的比较银屑病关节炎(PSA)和强直性脊柱炎(AS)中银屑病脊柱炎(PsSpA)的患病率、临床和影像特点。一项前瞻性的单中心横断面观察性研究招募了连续的PSA和AS病例。受试者完成结果测量，并接受临床检查、轴位X线片评分和人类白细胞抗原测序。并进行了多变量分析。402例入选病例(201例PSA，201例AS；符合各自条件的分类标准)根据放射学轴性疾病和银屑病重新分类为：PsSpA 118例，仅外周PSA(PPSA)127例，无银屑病(AS)的AS 157例。在轴性放射病患者中，有相当比例的患者有PsSpA(118/275；42.91%)，通常有无症状的轴性病变(30/118；25.42%)。修订的纽约AS标准符合48/201例(23.88%)PSA，按银屑病关节炎分类标准49/201(24.38%)符合AS。PPSA组与PsSpA组相比，HLAB*27基因频率降低(OR0.12；95%CI 0.05~0.25)。PsSpA和AS的疾病活动性、计量学和致残率相似。PsSpA患者中有很大比例的患者有脊柱炎而不伴有骶髂炎(39/118；33.05%)；他们携带HLA-B*27的频率较低(OR为0.11；95%CI为0.04~0.33)。与PsSpA相比，AS患者更可能出现完全性骶髂关节强直(调整OR，ORADJ2.96；95%可信区间1.42~6.15)和桥接关节突起(ORADJ2.78；95%可信区间1.49~5.18)。AS的放射学轴性病变比PsSpA更严重(银屑病关节炎脊柱炎放射学指数评分：调整后的发病率风险比1.13；95%可信区间1.09至1.19)。在来自同一中心的PSA或AS患者的联合队列中，24%的患者同时符合这两种情况的分类标准。皮肤银屑病和人类白细胞抗原B*27的存在显著影响中枢性疾病的类型。
To compare the prevalence, clinical and radiographic characteristics of psoriatic spondyloarthritis (PsSpA) in psoriatic arthritis (PsA), with ankylosing spondylitis (AS). A prospective single-centre cross-sectional observational study recruited consecutive PsA and AS cases. Participants completed outcome measures, and underwent clinical examination, axial radiographic scoring and HLA-sequencing. Multivariable analyses are presented. The 402 enrolled cases (201 PsA, 201 AS; fulfilling classification criteria for respective conditions) were reclassified based upon radiographic axial disease and psoriasis, as: 118 PsSpA, 127 peripheral-only PsA (pPsA), and 157 AS without psoriasis (AS) cases. A significant proportion of patients with radiographic axial disease had PsSpA (118/275; 42.91%), and often had symptomatically silent axial disease (30/118; 25.42%). Modified New York criteria for AS were fulfilled by 48/201 (23.88%) PsA cases, and Classification of Psoriatic Arthritis criteria by 49/201 (24.38%) AS cases. pPsA compared with PsSpA cases had a lower frequency of HLA-B*27 (OR 0.12; 95% CI 0.05 to 0.25). Disease activity, metrology and disability were comparable in PsSpA and AS. A significant proportion of PsSpA cases had spondylitis without sacroiliitis (39/118; 33.05%); they less frequently carried HLA-B*27 (OR 0.11; 95% CI 0.04 to 0.33). Sacroiliac joint complete ankylosis (adjusted OR, ORadj 2.96; 95% CI 1.42 to 6.15) and bridging syndesmophytes (ORadj 2.78; 95% CI 1.49 to 5.18) were more likely in AS than PsSpA. Radiographic axial disease was more severe in AS than PsSpA (Psoriatic Arthritis Spondylitis Radiology Index Score: adjusted incidence risk ratio 1.13; 95% CI 1.09 to 1.19). In a combined cohort of patients with either PsA or AS from a single centre, 24% fulfilled classification criteria for both conditions. The pattern of axial disease was influenced significantly by the presence of skin psoriasis and HLA-B*27.
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影响因子：
--
作者：
Haroon, Nigil;Inman, Robert D.;Learch, Thomas J.;Weisman, Michael H.;Lee, MinJae;Rahbar, Mohammad H.;Ward, Michael M.;Reveille, John D.;Gensler, Lianne S.
通讯作者：
Gensler, Lianne S.
影响因子：
27.4
作者：
Ash, Zoe R.;Tinazzi, Ilaria;Aydin, Sibel Z.
通讯作者：
Aydin, Sibel Z.
影响因子：
3.4
作者：
Kilic, Gamze;Kilic, Erkan;Ozgocmen, Salih
通讯作者：
Ozgocmen, Salih
影响因子：
27.4
作者：
Fransen, J.;Antoni, C.;Van Riel, P. L. C. M.
通讯作者：
Van Riel, P. L. C. M.
影响因子：
27.4
作者：
Helliwell, PS;Hickling, P;Wright, V
通讯作者：
Wright, V