PACAP signaling in stress: insights from the chromaffin cell.
PACAP signaling in stress: insights from the chromaffin cell.
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DOI：
10.1007/s00424-017-2062-3
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Smith CB
中科院分区：
文献类型：
--
作者：
Eiden LE;Emery AC;Zhang L;Smith CB
腺苷酸环化酶激活多肽（PACAP）首先在下丘脑中发现，基于其升高垂体前叶中环AMP的能力。在过去的二十年中，通过离体、体内和细胞实验的结合，PACAP已被确定为应激中的肾上腺髓质神经递质。在哺乳动物的应激事件中，PACAP引起儿茶酚胺分泌和儿茶酚胺生物合成酶的激活。PACAP信号的特点，允许在内脏神经肾上腺髓质突触的压力转导产生的见解乙酰胆碱和PACAP行动的对比作用，作为第一信使在嗜铬细胞，通过不同的内脏神经放电率的差异释放，和不同的信号通路，导致儿茶酚胺分泌和嗜铬细胞基因转录。在几个实验室中，在嗜铬细胞和副交感神经系统和交感神经系统的自主神经节内，通过独立于动作电位产生的钙内流，由PACAP刺激的儿茶酚胺分泌正在进行积极的研究。PACAP也是在中枢神经系统中的应激传导中重要的神经递质，并且发现于脑中的应激传导核团，包括下丘脑的室旁核、杏仁核和延伸杏仁核以及前额叶皮质。PACAP作为神经系统中应激信号的“主调节器”的当前状态从根本上源于其作为应激中肾上腺髓质递质的作用的建立，并且PACAP在该突触的作用的实验阐明仍然处于理解其在整个神经系统的应激信号中的作用的最前沿。
Pituitary adenylate cyclase-activating polypeptide (PACAP) was first identified in hypothalamus, based on its ability to elevate cyclic AMP in the anterior pituitary. PACAP has been identified as the adrenomedullary neurotransmitter in stress through a combination of ex vivo, in vivo, and in cellula experiments over the past two decades. PACAP causes catecholamine secretion, and activation of catecholamine biosynthetic enzymes, during episodes of stress in mammals. Features of PACAP signaling allowing stress transduction at the splanchnicoadrenomedullary synapse have yielded insights into the contrasting roles of acetylcholine and PACAP action as first messengers at the chromaffin cell, via differential release at different rates of splanchnic nerve firing, and different signaling pathways leading to catecholamine secretion and chromaffin cell gene transcription. Catecholamine secretion stimulated by PACAP, via calcium influx independent of action potential generation, is under active investigation in several laboratories, both at the chromaffin cell, and within autonomic ganglia of both the parasympathetic and sympathetic nervous systems. PACAP is a neurotransmitter important in stress transduction in the central nervous system as well, and is found at stress-transduction nuclei in brain including the paraventricular nucleus of hypothalamus, the amygdala and extended amygdalar nuclei, and the prefrontal cortex. The current status of PACAP as a ‘master regulator’ of stress signaling in the nervous system derives fundamentally from establishment of its role as the adrenomedullary transmitter in stress, and experimental elucidation of PACAP action at this synapse remains at the forefront of understanding its role in stress signaling throughout the nervous system.
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影响因子：
4
作者：
Ait-Ali, Djida;Samal, Babru;Eiden, Lee E.
通讯作者：
Eiden, Lee E.
影响因子：
7.3
作者：
DOUGLAS, WW
通讯作者：
DOUGLAS, WW
DOI：
10.1073/pnas.85.9.3240
发表时间：
1988-05-01
影响因子：
11.1
作者：
FISCHERCOLBRIE, R;IACANGELO, A;EIDEN, LE
通讯作者：
EIDEN, LE
影响因子：
4.7
作者：
EIDEN, LE;IACANGELO, A;AUNIS, D
通讯作者：
AUNIS, D
DOI：
10.1111/j.1749-6632.1987.tb27189.x
发表时间：
1987-04-24
影响因子：
5.2
作者：
FISCHERCOLBRIE, R;HAGN, C;SCHOBER, M
通讯作者：
SCHOBER, M