Keto-Functionalized Polymer Scaffolds As Versatile Precursors to Polymer Side Chain Conjugates.
Keto-Functionalized Polymer Scaffolds As Versatile Precursors to Polymer Side Chain Conjugates.
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DOI：
10.1021/ma302183g
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发表时间：
2013-01-01
期刊：
影响因子：
5.5
通讯作者：
Maynard HD
中科院分区：
文献类型：
--
作者：
Liu J;Li RC;Sand GJ;Bulmus V;Davis TP;Maynard HD
A new methacrylate monomer with a reactive ketone side-chain, 2-(4-oxo-pentanoate) ethyl methacrylate (PAEMA), was synthesized and subsequently polymerized by reversible addition-fragmentation chain transfer (RAFT) polymerization to give a polymer with a narrow molecular weight distribution (PDI = 1.25). The polymer was chain extended with poly(ethylene glycol methyl ether acrylate) (PEGMA) to yield a block copolymer. Aminooxy containing small molecules and oligoethylene glycol were conjugated to the ketone functionality of the side chain in high yields. Cytotoxicity of the oxime-linked tetra(ethylene glycol) polymer to mouse fibroblast cells was investigated; the polymer was found to be non-cytotoxic up to 1 mg/mL. The ease with which this polymer is functionalized, suggests that it may be useful in forming tailored polymeric medicines.
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影响因子：
--
作者：
Li, Ronald C.;Broyer, Rebecca M.;Maynard, Heather D.
通讯作者：
Maynard, Heather D.
影响因子：
15
作者：
Griffith, BR;Allen, BL;Kiessling, LL
通讯作者：
Kiessling, LL
影响因子：
5.5
作者：
Fournier, D;Pascual, S;Fontaine, L
通讯作者：
Fontaine, L
影响因子：
4.9
作者：
Li, Ronald C.;Hwang, Jungyeon;Maynard, Heather D.
通讯作者：
Maynard, Heather D.
影响因子：
6.2
作者：
Grover, Gregory N.;Lam, Jonathan;Nguyen, Thi H.;Segura, Tatiana;Maynard, Heather D.
通讯作者：
Maynard, Heather D.