Hippocampal ripples as a mode of communication with cortical and subcortical areas
Hippocampal ripples as a mode of communication with cortical and subcortical areas
复制标题
海马波纹作为与皮质和皮质下区域的沟通方式
作者：
Ralitsa Todorova;Michaël Zugaro
海马区尖锐的波纹复合体是高度同步的神经元活动的瞬时事件，通常发生在“脱机”大脑状态中。这种内生活动激增由行为相关的尖峰模式组成，描述了空间轨迹。它们已被证明在睡眠时记忆巩固和清醒时导航计划中起着关键作用。波纹除了对海马区产生局部影响外，还对目标皮层和皮质下区域产生直接和间接的影响，这些区域被认为在信息处理和语义网络重构中发挥着关键作用。我们回顾了关于海马区尖锐波纹功能的研究，特别关注了海马区与其皮质和皮质下靶点之间的信息流。首先，我们简要回顾了建立涟漪相关活动在认知过程中的因果作用的开创性工作。然后，我们回顾了海马波与皮质和皮质下活动的特定模式之间存在功能性相互作用的证据。最后，我们讨论了波纹和其他睡眠节律之间的功能耦合的关键作用，包括大脑皮层慢振荡和丘脑皮质睡眠纺锤波。
Hippocampal sharp wave‐ripple complexes are transient events of highly synchronous neuronal activity that typically occur during “offline” brain states. This endogenous surge of activity consists of behaviorally relevant spiking patterns, describing spatial trajectories. They have been shown to play a critical role in memory consolidation during sleep and in navigational planning during wakefulness. Beyond their local impact on the hippocampal formation, ripples also exert direct and indirect effects on target cortical and subcortical areas, which are thought to play a key role in information processing and semantic network reconfiguration. We review research into the function of hippocampal sharp waves‐ripples, with a special focus on information flow between the hippocampus and its cortical and subcortical targets. First, we briefly review seminal work establishing a causal role of ripple‐related activity in cognitive processes. We then review evidence for a functional interplay between hippocampal ripples and specific patterns of cortical and subcortical activity. Finally, we discuss the critical role of the functional coupling between ripples and other sleep rhythms, including the cortical slow oscillation and thalamocortical sleep spindles.
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影响因子：
16.2
作者：
Ngo, Hong-Viet V.;Martinetz, Thomas;Moelle, Matthias
通讯作者：
Moelle, Matthias
影响因子：
16.2
作者：
van de Ven GM;Trouche S;McNamara CG;Allen K;Dupret D
通讯作者：
Dupret D
影响因子：
16.6
作者：
Seibt J;Richard CJ;Sigl-Glöckner J;Takahashi N;Kaplan DI;Doron G;de Limoges D;Bocklisch C;Larkum ME
通讯作者：
Larkum ME
DOI：
10.1017/s1472928807000258
发表时间：
2005-12-01
期刊：
Thalamus & Related Systems
影响因子：
--
作者：
Sirota, Anton;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy