Mechanics and functional consequences of nuclear deformations.
Mechanics and functional consequences of nuclear deformations.
复制标题
核变形的力学和功能后果。
DOI：
10.1038/s41580-022-00480-z
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发表时间：
2022-09
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
作为细胞遗传信息的家园，细胞核在决定细胞的命运和功能方面起着关键作用，以响应各种信号和刺激。除了生化输入，细胞核不断暴露于内在和外在的机械力，触发核结构和形态的动态变化。新出现的数据表明，细胞核的物理变形调节许多细胞和核功能，这一直被认为是下游的细胞质信号通路和DNA基因组序列决定。在这篇综述中，我们讨论了一个新兴的观点，认为从染色质到核纤层和细胞骨架丝的物理连接作为一个单一的机械单位的遗传机制的mechanoregulation。我们描述了核变形的空间和时间协调的关键机制，并提供了一个关键的审查核变形的结构和功能的适应性反应。然后，我们考虑核变形的重要细胞功能，包括肌肉收缩，细胞迁移和人类疾病的发病机制的调节的贡献。总的来说，这些新的见解揭示了核变形的动力学及其在细胞机械生物学中的作用。
As the home of the cell’s genetic information, the nucleus plays a critical role in determining the cell’s fate and function in response to various signals and stimuli. In addition to biochemical inputs, the nucleus is constantly exposed to intrinsic and extrinsic mechanical forces that trigger dynamic changes in nuclear structure and morphology. Emerging data suggest that the physical deformation of the nucleus modulates many cellular and nuclear functions, which have long been considered downstream of cytoplasmic signaling pathways and dictated by DNA genomic sequences. In this Review, we discuss an emerging perspective on the mechanoregulation of the genetic machinery that considers the physical connections from chromatin to nuclear lamina and cytoskeletal filaments as a single mechanical unit. We describe key mechanisms of the spatial and temporal coordination of nuclear deformations and provide a critical review of the structural and functional adaptive responses of the nucleus to deformations. We then consider the contribution of nuclear deformations to the regulation of important cellular functions, including muscle contraction, cell migration, and human disease pathogenesis. Collectively, these emerging insights shed new light on the dynamics of nuclear deformations and their roles in cellular mechanobiology.
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影响因子：
8.8
作者：
Brown, M.;Roulson, J-A;Hart, C. A.;Tawadros, T.;Clarke, N. W.
通讯作者：
Clarke, N. W.
染色体不稳定性通过胞质DNA反应驱动转移。
影响因子：
64.8
作者：
Bakhoum SF;Ngo B;Laughney AM;Cavallo JA;Murphy CJ;Ly P;Shah P;Sriram RK;Watkins TBK;Taunk NK;Duran M;Pauli C;Shaw C;Chadalavada K;Rajasekhar VK;Genovese G;Venkatesan S;Birkbak NJ;McGranahan N;Lundquist M;LaPlant Q;Healey JH;Elemento O;Chung CH;Lee NY;Imielenski M;Nanjangud G;Pe'er D;Cleveland DW;Powell SN;Lammerding J;Swanton C;Cantley LC
通讯作者：
Cantley LC
影响因子：
9.2
作者：
Buxboim, Amnon;Swift, Joe;Irianto, Jerome;Spinler, Kyle R.;Dingal, P. C. Dave P.;Athirasala, Avathamsa;Kao, Yun-Ruei C.;Cho, Sangkyun;Harada, Takamasa;Shin, Jae-Won;Discher, Dennis E.
通讯作者：
Discher, Dennis E.
影响因子：
4.6
作者：
Bone, Courtney R.;Chang, Yu-Tai;Starr, Daniel A.
通讯作者：
Starr, Daniel A.
DOI：
10.4161/nucl.1.5.12830
发表时间：
2010-09
期刊：
Nucleus (Austin, Tex.)
影响因子：
--
作者：
Coffinier C;Fong LG;Young SG
通讯作者：
Young SG