SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions.
SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions.
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DOI：
10.1002/jcb.22076
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发表时间：
2009-04-15
影响因子：
4
通讯作者：
Shur, Barry D.
中科院分区：
文献类型：
--
作者：
Raymond, Adam;Ensslin, Michael A.;Shur, Barry D.
MFG-E8最初被认为是乳脂小球的主要成分，乳脂小球是一种被膜包裹的蛋白质和甘油三酯的集合，在哺乳期间从乳腺上皮的顶端表面萌芽。自那以后，它在许多物种和许多研究人员中被独立鉴定，并被赋予了各种名称，包括P47、乳粘附素、RAGS、PAS6/7和BA-46。首字母缩写SED1是为了使这一命名具有凝聚力，因为它是一种分泌型蛋白质，包含两个不同的功能结构域：N-末端结构域带有两个EGF-重复序列，其中第二个结构域具有整合素结合的RGD基序；C-末端结构域具有两个Discoidin/F5/8C结构域，与阴离子磷脂和/或细胞外基质结合。目前已知SED1/MFG-E8参与了多种细胞间的相互作用，包括吞噬凋亡的淋巴细胞和其他凋亡细胞、精子与卵子之间的粘连、肠粘膜的修复、乳腺分支形态的形成、血管生成等。这篇文章将探索SED1/MFG-E8的各种角色，以及它的挑衅性治疗潜力。
MFG-E8 was initially identified as a principle component of the Milk Fat Globule, a membrane-encased collection of proteins and triglycerides that bud from the apical surface of mammary epithelia during lactation. It has since been independently identified in many species and by many investigators and given a variety of names, including p47, lactadherin, rAGS, PAS6/7, and BA-46. The acronym SED1 was proposed to bring cohesion to this nomenclature based upon it being a Secreted protein that contains two distinct functional domains: an N-terminal domain with two EGF-repeats, the second of which has an integrin-binding RGD motif, and a C-terminal domain with two Discoidin/F5/8C domains that bind to anionic phospholipids and/or extracellular matrices. SED1/MFG-E8 is now known to participate in a wide variety of cellular interactions, including phagocytosis of apoptotic lymphocytes and other apoptotic cells, adhesion between sperm and the egg coat, repair of intestinal mucosa, mammary gland branching morphogenesis, angiogenesis, among others. This article will explore the various roles proposed for SED1/MFG-E8, as well as its provocative therapeutic potential.
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影响因子：
64.5
作者：
Ensslin, MA;Shur, BD
通讯作者：
Shur, BD
DOI：
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发表时间：
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影响因子：
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