Towards principled design of cancer nanomedicine to accelerate clinical translation.
Towards principled design of cancer nanomedicine to accelerate clinical translation.
复制标题
DOI：
10.1016/j.mtbio.2022.100208
复制
发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Munn LL
中科院分区：
文献类型：
--
作者：
Souri M;Soltani M;Moradi Kashkooli F;Kiani Shahvandi M;Chiani M;Shariati FS;Mehrabi MR;Munn LL
纳米技术在医学上的应用，特别是在肿瘤学中作为药物输送系统，最近显示出了有希望的结果。然而，尽管这些进展在临床前阶段很有希望，但这项技术的临床转化具有挑战性。为了创建具有更高临床转译治疗效果的药物输送系统，可以指定纳米颗粒的物理化学特性，如大小、形状、弹性（柔韧性/刚性）、表面化学和表面电荷，以优化给定应用的效率。因此，跨学科研究人员专注于生产生物相容性材料、生产技术或高效加载和高稳定性的新配方。设计参数的影响可以在体外、体内或使用计算模型进行研究，目的是了解它们如何影响纳米颗粒生物物理及其与细胞的相互作用。本文综述了抗癌纳米药物的生产和设计，以实现临床转化和商业化的进展和技术。我们还强调了该领域现有的挑战和机遇。
Nanotechnology in medical applications, especially in oncology as drug delivery systems, has recently shown promising results. However, although these advances have been promising in the pre-clinical stages, the clinical translation of this technology is challenging. To create drug delivery systems with increased treatment efficacy for clinical translation, the physicochemical characteristics of nanoparticles such as size, shape, elasticity (flexibility/rigidity), surface chemistry, and surface charge can be specified to optimize efficiency for a given application. Consequently, interdisciplinary researchers have focused on producing biocompatible materials, production technologies, or new formulations for efficient loading, and high stability. The effects of design parameters can be studied in vitro, in vivo, or using computational models, with the goal of understanding how they affect nanoparticle biophysics and their interactions with cells. The present review summarizes the advances and technologies in the production and design of cancer nanomedicines to achieve clinical translation and commercialization. We also highlight existing challenges and opportunities in the field.
登录
查看更多内容
影响因子：
17.1
作者：
Anchordoquy TJ;Barenholz Y;Boraschi D;Chorny M;Decuzzi P;Dobrovolskaia MA;Farhangrazi ZS;Farrell D;Gabizon A;Ghandehari H;Godin B;La-Beck NM;Ljubimova J;Moghimi SM;Pagliaro L;Park JH;Peer D;Ruoslahti E;Serkova NJ;Simberg D
通讯作者：
Simberg D
影响因子：
17.1
作者：
Anselmo, Aaron C.;Zhang, Mengwen;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
13.3
作者：
Bartczak, Dorota;Muskens, Otto L.;Kanaras, Antonios G.
通讯作者：
Kanaras, Antonios G.
影响因子：
11.2
作者：
Abbasi, Azhar Z.;Gordijo, Claudia R.;Wu, Xiao Yu
通讯作者：
Wu, Xiao Yu
影响因子：
6.7
作者：
Bleul, Regina;Thiermann, Raphael;Maskos, Michael
通讯作者：
Maskos, Michael