Placental miRNAs Targeting Cellular Stress Response Pathways Are Highly Expressed in Non-Hispanic Black People.
Placental miRNAs Targeting Cellular Stress Response Pathways Are Highly Expressed in Non-Hispanic Black People.
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靶向细胞应激反应途径的胎盘miRNAs在非西班牙裔黑人中高度表达
DOI：
10.1007/s43032-022-00895-1
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发表时间：
2022-07
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
非西班牙裔黑人（NHB）与非西班牙裔白色（NHW）相比，孕产妇死亡风险高2.5倍。NHB人群的新生儿更有可能早产，胎龄较小，这可能是由结构性种族主义造成的。胎盘对母体环境非常敏感，可能在环境压力因素转化为妊娠结局方面发挥关键作用。我们的目的是评估NHB和NHW人群胎盘miRNA表达谱，以及差异表达的miRNA与妊娠结局之间的关系。胎盘收集自50名NHB和74名NHW正常单胎妊娠的人，在分娩前进行择期剖宫产。通过全基因组小RNA测序在77个胎盘的子集中测量胎盘miRNA表达。15种miRNAs在NHB人群的胎盘中表达更高。其中一些miRNA与细胞应激反应途径相关，表明它们可能对环境应激源做出反应。胎盘miR-192- 5 p表达在NHB人群中较低，并且与新生儿肥胖呈正相关，这表明它可能对结构种族主义敏感，对胎儿生长具有潜在影响。
Non-Hispanic Black (NHB) people have 2.5 fold higher risk of maternal mortality when compared no Non-Hispanic White (NHW) people. Neonates of NHB people are more likely to be born preterm and small for gestational age which may be driven by structural racism. The placenta is very sensitive to the maternal environment, and may play a critical role in the translation of environmental stressors to pregnancy outcomes. Our aim was to assess the placental miRNA expression profile in both NHB and NHW people, and the association between differentially expressed miRNAs and pregnancy outcomes. Placentas were collected from 50 NHB, and 74 NHW people with a normal singleton pregnancy undergoing elective cesarean section at term prior to the onset of labor. Placental miRNA expression was measured via whole genome small RNA-sequencing in a subset of 77 placentas. Fifteen miRNAs were more highly expressed in placentas of NHB people. Several of these miRNA were associated with cellular stress response pathways, suggesting that they may be responding to environmental stressors. Placental miR-192-5p expression was lower among NHB people, and was positively associated with neonatal adiposity, suggesting it may be sensitive to structural racism with potential impacts on fetal growth.
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影响因子：
2.9
作者：
Lampl, Michelle;Lee, Wesley;Koo, Winston;Frongillo, Edward A.;Barker, David J. P.;Romero, Roberto
通讯作者：
Romero, Roberto
影响因子：
9.8
作者：
Jones CW;Gambala C;Esteves KC;Wallace M;Schlesinger R;O'Quinn M;Kidd L;Theall KP;Drury SS
通讯作者：
Drury SS
DOI：
10.1093/bioinformatics/btx752
发表时间：
2018-04-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Fabregat A;Sidiropoulos K;Viteri G;Marin-Garcia P;Ping P;Stein L;D'Eustachio P;Hermjakob H
通讯作者：
Hermjakob H
影响因子：
14.9
作者：
Karagkouni D;Paraskevopoulou MD;Chatzopoulos S;Vlachos IS;Tastsoglou S;Kanellos I;Papadimitriou D;Kavakiotis I;Maniou S;Skoufos G;Vergoulis T;Dalamagas T;Hatzigeorgiou AG
通讯作者：
Hatzigeorgiou AG
影响因子：
14.9
作者：
Chang, Le;Zhou, Guangyan;Xia, Jianguo
通讯作者：
Xia, Jianguo