Theoretical Predictions for Spatially-Focused Heating of Magnetic Nanoparticles Guided by Magnetic Particle Imaging Field Gradients.
Theoretical Predictions for Spatially-Focused Heating of Magnetic Nanoparticles Guided by Magnetic Particle Imaging Field Gradients.
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DOI：
10.1016/j.jmmm.2016.06.038
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发表时间：
2016-12-01
影响因子：
2.7
通讯作者：
Rinaldi C
中科院分区：
文献类型：
--
作者：
Dhavalikar R;Rinaldi C
交变磁场中的磁性纳米颗粒（AMF）将一些场的能量以热的形式转移到周围环境中，这一特性引起了人们的极大关注，用于通过热疗治疗癌症和开发磁性药物载体，这些载体可以被驱动以使用磁场在外部释放其货物。迄今为止，该领域的大多数工作集中在使用AMF，其在大区域上通过纳米颗粒致动热释放，而没有选择特定的纳米颗粒负载区域进行加热同时使其他纳米颗粒负载区域不受影响的能力。与此同时，磁粒子成像（MPI）已成为一种有前途的方法来成像的磁性纳米粒子示踪剂在体内的分布，与亚毫米空间分辨率。MPI中的基本原理是应用选择磁场梯度，其限定了小的低偏置场区域，与AMF（其频率和幅度低于通常用于通过纳米颗粒致动加热的频率和幅度）叠加，以获得与低偏置场区域中的颗粒浓度成比例的信号。在这里，我们扩展了以前的模型，用于估计均匀AMF中的磁性纳米颗粒的能量耗散率，以提供理论预测，即MPI中使用的选择磁场梯度如何可以用于选择性地致动加热的磁性纳米颗粒在选择磁场梯度的低偏置场区域。理论预测的能量耗散率的空间衰减下的磁场梯度的代表，可以实现与当前的MPI技术。这些结果强调了MPI和更高的振幅/频率驱动AMF相结合，以实现选择性磁流体热疗（MFH）MPI引导的潜力。
Magnetic nanoparticles in alternating magnetic fields (AMFs) transfer some of the field’s energy to their surroundings in the form of heat, a property that has attracted significant attention for use in cancer treatment through hyperthermia and in developing magnetic drug carriers that can be actuated to release their cargo externally using magnetic fields. To date, most work in this field has focused on the use of AMFs that actuate heat release by nanoparticles over large regions, without the ability to select specific nanoparticle-loaded regions for heating while leaving other nanoparticle-loaded regions unaffected. In parallel, magnetic particle imaging (MPI) has emerged as a promising approach to image the distribution of magnetic nanoparticle tracers in vivo, with sub-millimeter spatial resolution. The underlying principle in MPI is the application of a selection magnetic field gradient, which defines a small region of low bias field, superimposed with an AMF (of lower frequency and amplitude than those normally used to actuate heating by the nanoparticles) to obtain a signal which is proportional to the concentration of particles in the region of low bias field. Here we extend previous models for estimating the energy dissipation rates of magnetic nanoparticles in uniform AMFs to provide theoretical predictions of how the selection magnetic field gradient used in MPI can be used to selectively actuate heating by magnetic nanoparticles in the low bias field region of the selection magnetic field gradient. Theoretical predictions are given for the spatial decay in energy dissipation rate under magnetic field gradients representative of those that can be achieved with current MPI technology. These results underscore the potential of combining MPI and higher amplitude/frequency actuation AMFs to achieve selective magnetic fluid hyperthermia (MFH) guided by MPI.
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影响因子：
38.3
作者：
Lee, Jae-Hyun;Jang, Jung-tak;Cheon, Jinwoo
通讯作者：
Cheon, Jinwoo
影响因子：
3.2
作者：
Dejardin, P. M.;Kalmykov, Yu. P.;Titov, S. V.
通讯作者：
Titov, S. V.
DOI：
10.1016/j.ejmp.2012.08.005
发表时间：
2013-11-01
影响因子：
3.4
作者：
Murase, Kenya;Takata, Hiroshige;Saito, Shigeyoshi
通讯作者：
Saito, Shigeyoshi
影响因子：
2.1
作者：
Ho, S. L.;Niu, Shuangxia;Fu, W. N.
通讯作者：
Fu, W. N.
影响因子：
17.1
作者：
Kolosnjaj-Tabi, Jelena;Di Corato, Riccardo;Gazeau, Florence
通讯作者：
Gazeau, Florence