Cortical Regions Activated by Spectrally Degraded Speech in Adults With Single Sided Deafness or Bilateral Normal Hearing.
Cortical Regions Activated by Spectrally Degraded Speech in Adults With Single Sided Deafness or Bilateral Normal Hearing.
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DOI：
10.3389/fnins.2021.618326
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发表时间：
2021
影响因子：
4.3
通讯作者：
Firszt JB
中科院分区：
文献类型：
--
作者：
Burton H;Reeder RM;Holden T;Agato A;Firszt JB
单侧耳聋（SSD）引起的深度感音神经性听力损失患者在不利的声音环境中通常会经历更大的认知努力和疲劳。我们研究了右耳SSD病例与正常听力（NH）个体的比较。SSD的情况下，显着不正确的命名最后一个词在频谱退化的8和16波段声码的句子，尽管语义的可预测性高。组间差异不显着较难理解的4带句子，无论可预测性。SSD在左半球（LH）早期听觉、听觉联合、下额叶、运动前区、下顶叶、背外侧前额叶、后扣带回、颞顶叶枕叶交界处和后鳃盖区的皮质区域中也有减少的BOLD百分比信号变化。在SSD中具有比NH更低幅度反应的皮层区域主要是LH语言网络的组成部分，先前指出与语音识别有关。记录的BOLD信号幅度是来自这些皮层区域的预定义包裹内的所有顶点的平均值。来自SSD中不同区域的Paramount对更高可懂度的句子显示出显著更大的信号幅度（例如，8-或16对4波段），除了早期听觉和后扣带皮层。显着较低的响应幅度发生在SSD比NH在以前的研究发现负责语音和音韵的语音，认知提取的意义，控制检索的词义和语义的区域。研究结果表明，SSD中LH额颞顶叶网络的激活减少导致难以处理单词意义和句子语义的语音。SSD经历的努力倾听可能反映了受影响的LH语言网络包裹中对退化语音的激活减少。SSD显示在匹配的右半球包裹没有代偿活动。
Those with profound sensorineural hearing loss from single sided deafness (SSD) generally experience greater cognitive effort and fatigue in adverse sound environments. We studied cases with right ear, SSD compared to normal hearing (NH) individuals. SSD cases were significantly less correct in naming last words in spectrally degraded 8- and 16-band vocoded sentences, despite high semantic predictability. Group differences were not significant for less intelligible 4-band sentences, irrespective of predictability. SSD also had diminished BOLD percent signal changes to these same sentences in left hemisphere (LH) cortical regions of early auditory, association auditory, inferior frontal, premotor, inferior parietal, dorsolateral prefrontal, posterior cingulate, temporal-parietal-occipital junction, and posterior opercular. Cortical regions with lower amplitude responses in SSD than NH were mostly components of a LH language network, previously noted as concerned with speech recognition. Recorded BOLD signal magnitudes were averages from all vertices within predefined parcels from these cortex regions. Parcels from different regions in SSD showed significantly larger signal magnitudes to sentences of greater intelligibility (e.g., 8- or 16- vs. 4-band) in all except early auditory and posterior cingulate cortex. Significantly lower response magnitudes occurred in SSD than NH in regions prior studies found responsible for phonetics and phonology of speech, cognitive extraction of meaning, controlled retrieval of word meaning, and semantics. The findings suggested reduced activation of a LH fronto-temporo-parietal network in SSD contributed to difficulty processing speech for word meaning and sentence semantics. Effortful listening experienced by SSD might reflect diminished activation to degraded speech in the affected LH language network parcels. SSD showed no compensatory activity in matched right hemisphere parcels.
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影响因子：
3.7
作者：
Firszt JB;Reeder RM;Holden LK
通讯作者：
Holden LK
DOI：
10.1093/cercor/bht083
发表时间：
2014-09
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Evans S;Kyong JS;Rosen S;Golestani N;Warren JE;McGettigan C;Mourão-Miranda J;Wise RJ;Scott SK
通讯作者：
Scott SK
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
DOI：
10.1111/j.1749-6632.1976.tb25546.x
发表时间：
1976-01-01
影响因子：
5.2
作者：
BOGEN, JE;BOGEN, GM
通讯作者：
BOGEN, GM
影响因子：
5.3
作者：
Boynton, GM;Engel, SA;Heeger, DJ
通讯作者：
Heeger, DJ