The pathways for intelligible speech: multivariate and univariate perspectives.
The pathways for intelligible speech: multivariate and univariate perspectives.
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DOI：
10.1093/cercor/bht083
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Scott SK
中科院分区：
文献类型：
--
作者：
Evans S;Kyong JS;Rosen S;Golestani N;Warren JE;McGettigan C;Mourão-Miranda J;Wise RJ;Scott SK
在非人类灵长类动物中，已经发现了一条与从声音中提取意义有关的前通路。在人类中也有类似的通路，但关于侧化的程度和对可理解语言的反应出现的精确位置存在争议。我们已经证明左前上级颞沟（STS）优先响应可理解的语言（Scott SK，Blank CC，罗森S，Wise RJS. 2000.左颞叶可理解言语通路的识别。个脑袋123：2400-2406）。大脑皮层的功能性磁共振成像研究使用等效刺激以及单变量和多变量分析来证明，与左前STS相比，双侧后STS在对可理解的语言做出反应时具有更大的重要性（Okada K，Rong F，Venezia J，Matchin W，Hsieh IH，Saberi K，Seberian JT，Hickok G. 2010.人类听觉皮层的层级组织：对可理解语音反应的声学不变性证据。20：2486-2495）。在这里，我们也复制我们原来的研究，表明左前STS表现出最强的单变量响应，并在解码使用双侧颞叶皮层，包含最丰富的体素显示增加的响应可理解的语音。相比之下，在使用局部“探照灯”和全脑分析的分类中，我们发现后颞区比前颞区的分类准确性更高。因此，我们表明，所使用的多元分析的精确性质将强调与复杂的声音语音处理相关的不同的响应曲线。
An anterior pathway, concerned with extracting meaning from sound, has been identified in nonhuman primates. An analogous pathway has been suggested in humans, but controversy exists concerning the degree of lateralization and the precise location where responses to intelligible speech emerge. We have demonstrated that the left anterior superior temporal sulcus (STS) responds preferentially to intelligible speech (Scott SK, Blank CC, Rosen S, Wise RJS. 2000. Identification of a pathway for intelligible speech in the left temporal lobe. Brain. 123:2400–2406.). A functional magnetic resonance imaging study in Cerebral Cortex used equivalent stimuli and univariate and multivariate analyses to argue for the greater importance of bilateral posterior when compared with the left anterior STS in responding to intelligible speech (Okada K, Rong F, Venezia J, Matchin W, Hsieh IH, Saberi K, Serences JT,Hickok G. 2010. Hierarchical organization of human auditory cortex: evidence from acoustic invariance in the response to intelligible speech. 20: 2486–2495.). Here, we also replicate our original study, demonstrating that the left anterior STS exhibits the strongest univariate response and, in decoding using the bilateral temporal cortex, contains the most informative voxels showing an increased response to intelligible speech. In contrast, in classifications using local “searchlights” and a whole brain analysis, we find greater classification accuracy in posterior rather than anterior temporal regions. Thus, we show that the precise nature of the multivariate analysis used will emphasize different response profiles associated with complex sound to speech processing.
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