Polygenic risk for type 2 diabetes, lifestyle, metabolic health, and cardiovascular disease: a prospective UK Biobank study.
Polygenic risk for type 2 diabetes, lifestyle, metabolic health, and cardiovascular disease: a prospective UK Biobank study.
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2型糖尿病，生活方式，代谢健康和心血管疾病的多基因风险：前瞻性英国生物库研究。
DOI：
10.1186/s12933-022-01560-2
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发表时间：
2022-07-14
影响因子：
9.3
通讯作者：
中科院分区：
文献类型：
--
作者：
很少有研究调查2型糖尿病（T2D）的遗传风险、生活方式、临床危险因素和心血管疾病（CVD）之间的关系。我们的目的是调查T2D遗传风险、生活方式行为和代谢风险因素与CVD之间的关联和潜在的相互作用。共有345217名无血缘关系的英国白人参与了分析。T2D的遗传风险是通过由600万个遗传变异构建的全基因组多基因风险评分来估计的。根据四种可改变的生活方式成分来定义良好的生活方式，并根据代谢综合征成分的存在来确定代谢健康状况。在中位随访8.9年期间，确定了21865例CVD病例（6.3%）。与低遗传风险组相比，T2D遗传风险高的参与者总体CVD事件、CVD亚型（冠状动脉疾病、外周动脉疾病、心力衰竭和心房颤动/扑动）和CVD死亡率更高。T2D遗传风险非常高的个体患CVD的风险比遗传风险低的个体高35% （HR 1.35 [95% CI 1.19 ~ 1.53]）。在遗传风险、生活方式和代谢健康状态中观察到CVD风险增加的显著梯度（趋势P < 0.001）。无论T2D遗传风险如何，生活方式良好且代谢健康的患者CVD事件风险显著降低。这种风险降低在年轻参与者（≤50岁）中更为明显。T2D的遗传风险与总体CVD、各种CVD亚型和致死性CVD的风险增加相关。无论T2D的遗传风险如何，保持健康的生活方式和保持代谢健康都可能降低CVD的后续风险。在线版本包含补充材料，可在10.1186/s12933-022-01560-2获得。
Few studies have examined associations between genetic risk for type 2 diabetes (T2D), lifestyle, clinical risk factors, and cardiovascular disease (CVD). We aimed to investigate the association of and potential interactions among genetic risk for T2D, lifestyle behavior, and metabolic risk factors with CVD. A total of 345,217 unrelated participants of white British descent were included in analyses. Genetic risk for T2D was estimated as a genome-wide polygenic risk score constructed from > 6 million genetic variants. A favorable lifestyle was defined in terms of four modifiable lifestyle components, and metabolic health status was determined according to the presence of metabolic syndrome components. During a median follow-up of 8.9 years, 21,865 CVD cases (6.3%) were identified. Compared with the low genetic risk group, participants at high genetic risk for T2D had higher rates of overall CVD events, CVD subtypes (coronary artery disease, peripheral artery disease, heart failure, and atrial fibrillation/flutter), and CVD mortality. Individuals at very high genetic risk for T2D had a 35% higher risk of CVD than those with low genetic risk (HR 1.35 [95% CI 1.19 to 1.53]). A significant gradient of increased CVD risk was observed across genetic risk, lifestyle, and metabolic health status (P for trend > 0.001). Those with favorable lifestyle and metabolically healthy status had significantly reduced risk of CVD events regardless of T2D genetic risk. This risk reduction was more apparent in young participants (≤ 50 years). Genetic risk for T2D was associated with increased risks of overall CVD, various CVD subtypes, and fatal CVD. Engaging in a healthy lifestyle and maintaining metabolic health may reduce subsequent risk of CVD regardless of genetic risk for T2D. The online version contains supplementary material available at 10.1186/s12933-022-01560-2.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
英国生物库中的遗传分析将胰岛素抵抗和跨内皮迁移途径与冠状动脉疾病联系起来。
影响因子：
30.8
作者：
Klarin D;Zhu QM;Emdin CA;Chaffin M;Horner S;McMillan BJ;Leed A;Weale ME;Spencer CCA;Aguet F;Segrè AV;Ardlie KG;Khera AV;Kaushik VK;Natarajan P;CARDIoGRAMplusC4D Consortium;Kathiresan S
通讯作者：
Kathiresan S
DOI：
10.1056/nejmoa1605086
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Khera AV;Emdin CA;Drake I;Natarajan P;Bick AG;Cook NR;Chasman DI;Baber U;Mehran R;Rader DJ;Fuster V;Boerwinkle E;Melander O;Orho-Melander M;Ridker PM;Kathiresan S
通讯作者：
Kathiresan S
影响因子：
37.8
作者：
Dekker, JM;Girman, C;Heine, RJ
通讯作者：
Heine, RJ
影响因子：
8.3
作者：
Jennings, Catriona;Astin, Felicity
通讯作者：
Astin, Felicity