Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.
Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.
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DOI：
10.1016/j.stem.2012.12.015
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发表时间：
2013-03-07
期刊：
影响因子：
23.9
通讯作者：
Nedergaard, Maiken
中科院分区：
文献类型：
--
作者：
Han, Xiaoning;Chen, Michael;Wang, Fushun;Windrem, Martha;Wang, Su;Shanz, Steven;Xu, Qiwu;Oberheim, Nancy Ann;Bekar, Lane;Betstadt, Sarah;Silva, Alcino J.;Takano, Takahiro;Goldman, Steven A.;Nedergaard, Maiken
人类星形胶质细胞比灵长类以下哺乳动物的星形胶质细胞更大、更复杂，这表明它们在神经处理中的作用随着进化而扩大。为了评估人类神经胶质细胞的细胞自主性和物种选择性，我们将人神经胶质前体细胞(GPC)移植到新生免疫缺陷小鼠体内。在成熟后，受体大脑显示出大量和高比例的人类神经胶质前体细胞和星形胶质细胞。移植的人脑胶质细胞与宿主星形胶质细胞呈缝隙连接，但保留了类人型星形胶质细胞的大小和多形性，并且钙信号的传播速度比宿主快3倍。长时程增强(LTP)在人类神经胶质嵌合小鼠中显著增强，正如它们的学习能力一样，通过Barnes迷宫导航、物体位置记忆以及上下文和音调恐惧条件反射来评估。移植了小鼠GPC的小鼠没有表现出LTP或学习能力的增强。这些发现表明，人类胶质细胞在不同程度上增强了小鼠的活动依赖性可塑性和学习能力。
Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution. To assess the cell-autonomous and species-selective properties of human glia, we engrafted human glial progenitor cells (GPCs) into neonatal immunodeficient mice. Upon maturation, the recipient brains exhibited large numbers and high proportions of both human glial progenitors and astrocytes. The engrafted human glia were gap junction-coupled to host astroglia, yet retained the size and pleomorphism of hominid astroglia, and propagated Ca2+ signals 3-fold faster than their hosts. Long term potentiation (LTP) was sharply enhanced in the human glial chimeric mice, as was their learning, as assessed by Barnes maze navigation, object-location memory, and both contextual and tone fear conditioning. Mice allografted with murine GPCs showed no enhancement of either LTP or learning. These findings indicate that human glia differentially enhance both activity-dependent plasticity and learning in mice.
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影响因子：
34.7
作者：
Lee, Yong-Seok;Silva, Alcino J.
通讯作者：
Silva, Alcino J.
影响因子：
16.2
作者：
Kang, Shin H.;Fukaya, Masahiro;Yang, Jason K.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
DOI：
10.1523/jneurosci.4707-08.2009
发表时间：
2009-03-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Oberheim NA;Takano T;Han X;He W;Lin JH;Wang F;Xu Q;Wyatt JD;Pilcher W;Ojemann JG;Ransom BR;Goldman SA;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
3
作者：
Fields, RD
通讯作者：
Fields, RD
影响因子：
2.5
作者：
GROVER, LM;TEYLER, TJ
通讯作者：
TEYLER, TJ