Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes.
Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes.
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DOI：
10.1371/journal.pone.0056823
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hayes DN
中科院分区：
文献类型：
--
作者：
Walter V;Yin X;Wilkerson MD;Cabanski CR;Zhao N;Du Y;Ang MK;Hayward MC;Salazar AH;Hoadley KA;Fritchie K;Sailey CJ;Weissler MC;Shockley WW;Zanation AM;Hackman T;Thorne LB;Funkhouser WD;Muldrew KL;Olshan AF;Randell SH;Wright FA;Shores CG;Hayes DN
头颈鳞状细胞癌（HNSCC）是一种经常致命的异质性疾病。除了人乳头瘤病毒 (HPV) 的作用之外，尚未确定该疾病的经过验证的分子特征。使用集成的基因组分析和验证方法，我们确认了 HNSCC 的四种分子类别（基底型、间质型、非典型型和经典型）与肺鳞状细胞癌建立的特征一致，包括 KEAP1/NFE2L2 氧化应激途径的失调、谱系标记 SOX2 和 TP63 的差异利用以及对癌基因的偏好 PIK3CA 和 EGFR。对于潜在的临床用途，这些特征是对 HPV 感染状态分类以及推定的高风险标记 CCND1 拷贝数增益的补充。统计学上显着的染色体获得和丢失以及差异细胞起源表达模式表明了亚型的分子病因学。还提出了代表四种亚型中每一种亚型的模型系统。
Head and neck squamous cell carcinoma (HNSCC) is a frequently fatal heterogeneous disease. Beyond the role of human papilloma virus (HPV), no validated molecular characterization of the disease has been established. Using an integrated genomic analysis and validation methodology we confirm four molecular classes of HNSCC (basal, mesenchymal, atypical, and classical) consistent with signatures established for squamous carcinoma of the lung, including deregulation of the KEAP1/NFE2L2 oxidative stress pathway, differential utilization of the lineage markers SOX2 and TP63, and preference for the oncogenes PIK3CA and EGFR. For potential clinical use the signatures are complimentary to classification by HPV infection status as well as the putative high risk marker CCND1 copy number gain. A molecular etiology for the subtypes is suggested by statistically significant chromosomal gains and losses and differential cell of origin expression patterns. Model systems representative of each of the four subtypes are also presented.
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影响因子：
14.9
作者：
Hu Y;Huang Y;Du Y;Orellana CF;Singh D;Johnson AR;Monroy A;Kuan PF;Hammond SM;Makowski L;Randell SH;Chiang DY;Hayes DN;Jones C;Liu Y;Prins JF;Liu J
通讯作者：
Liu J
影响因子：
11.2
作者：
Chatterjee A;Chang X;Sen T;Ravi R;Bedi A;Sidransky D
通讯作者：
Sidransky D
影响因子：
5.2
作者：
Chen C;Köberle B;Kaufmann AM;Albers AE
通讯作者：
Albers AE
影响因子：
3.7
作者：
Hackett NR;Shaykhiev R;Walters MS;Wang R;Zwick RK;Ferris B;Witover B;Salit J;Crystal RG
通讯作者：
Crystal RG
影响因子：
9.7
作者：
Fujii, M;Ishiguro, R;Tashiro, M
通讯作者：
Tashiro, M