Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex.
Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex.
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DOI：
10.1038/s41598-021-85802-5
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发表时间：
2021-03-18
影响因子：
4.6
通讯作者：
Hervey-Jumper SL
中科院分区：
文献类型：
--
作者：
Aabedi AA;Kakaizada S;Young JS;Kaur J;Wiese O;Valdivia C;Krishna S;Weyer-Jamora C;Berger MS;Weissman DH;Brang D;Hervey-Jumper SL
词汇检索需要从词典中选择和检索最合适的单词来表达所需的概念。很少有研究探讨图片命名以外的词汇检索任务，并且当应用非图片命名词汇检索任务时，会出现趋同和发散的结果。词汇检索的听觉和视觉过程的单一结构的存在将影响失语症患者的认知康复策略。在这项研究中，我们使用脑肿瘤模型进行支持向量回归病变症状映射，以测试以下假设：专门参与视觉和听觉刺激词汇检索的大脑区域代表重叠的神经系统。我们发现，语言任务的主成分分析揭示了图片命名、听觉命名和单词发现的有效测量之间的多重共线性，这意味着冗余认知结构的存在。参与者之间的非参数、多变量病变症状映射被用来模拟四种语言任务中每一种的准确性。左侧前额叶皮层 (PFC) 中 8,333 个体素和 21,512 个体素重叠簇内的病变分别预示着图像命名和听觉命名受损。这些数据表明 PFC 内异模态词汇检索的收敛。
Lexical retrieval requires selecting and retrieving the most appropriate word from the lexicon to express a desired concept. Few studies have probed lexical retrieval with tasks other than picture naming, and when non-picture naming lexical retrieval tasks have been applied, both convergent and divergent results emerged. The presence of a single construct for auditory and visual processes of lexical retrieval would influence cognitive rehabilitation strategies for patients with aphasia. In this study, we perform support vector regression lesion-symptom mapping using a brain tumor model to test the hypothesis that brain regions specifically involved in lexical retrieval from visual and auditory stimuli represent overlapping neural systems. We find that principal components analysis of language tasks revealed multicollinearity between picture naming, auditory naming, and a validated measure of word finding, implying the existence of redundant cognitive constructs. Nonparametric, multivariate lesion-symptom mapping across participants was used to model accuracies on each of the four language tasks. Lesions within overlapping clusters of 8,333 voxels and 21,512 voxels in the left lateral prefrontal cortex (PFC) were predictive of impaired picture naming and auditory naming, respectively. These data indicate a convergence of heteromodal lexical retrieval within the PFC.
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影响因子：
4.1
作者：
Aabedi, Alexander A.;Ahn, EunSeon;Hervey-Jumper, Shawn L.
通讯作者：
Hervey-Jumper, Shawn L.
影响因子：
3.7
作者：
Friederici, AD;Opitz, B;von Cramon, DY
通讯作者：
von Cramon, DY
影响因子：
3.6
作者：
Benavides-Varela, Silvia;Passarini, Laura;Semenza, Carlo
通讯作者：
Semenza, Carlo
影响因子：
4.8
作者：
DeMarco AT;Turkeltaub PE
通讯作者：
Turkeltaub PE
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group