Vitamin D Supplementation and Non-Alcoholic Fatty Liver Disease: Present and Future.
Vitamin D Supplementation and Non-Alcoholic Fatty Liver Disease: Present and Future.
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DOI：
10.3390/nu9091015
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发表时间：
2017-09-14
期刊：
影响因子：
5.9
通讯作者：
Cavallo MG
中科院分区：
文献类型：
--
作者：
Barchetta I;Cimini FA;Cavallo MG
非酒精性脂肪肝病（NAFLD）是西方世界最常见的慢性肝病，被认为是隐源性肝硬化的主要原因；然而，寻找 NAFLD 的有效治疗方法仍然是一个重大挑战。维生素 D 缺乏症是一种广泛存在的疾病，在工业化国家达到流行病的程度，这主要与当前的生活方式和有限的饮食来源有关。流行病学研究表明，维生素 D 缺乏症与 NAFLD 和脂肪性肝炎 (NASH) 之间存在关联，与肥胖和胰岛素抵抗等混杂因素无关。此外，多项实验数据显示维生素 D 对肝细胞具有抗纤维化、抗炎和胰岛素增敏特性。然而，评估口服维生素 D 补充剂对 NAFLD 和 NASH 肝损伤影响的试验结果存在争议。本综述的目的是概述目前从临床试验中获得的证据，并讨论可能的缺点和未来研究中需要考虑的新策略。
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic disease throughout the Western world and is recognized as the main cause of cryptogenic cirrhosis; however, the identification of an effective therapy for NAFLD is still a major challenge. Vitamin D deficiency is a wide-spread condition which reaches epidemic proportions in industrialized countries, mainly in relation to current lifestyle and limited dietary sources. Epidemiological studies point towards an association between hypovitaminosis D and the presence of NAFLD and steatohepatitis (NASH), independently of confounders such as obesity and insulin resistance. Furthermore, several pieces of experimental data have shown the anti-fibrotic, anti-inflammatory and insulin-sensitizing properties exerted by vitamin D on hepatic cells. However, results from trials evaluating the effects of oral vitamin D supplementation on liver damage in NAFLD and NASH are controversial. The aim of this review is to give an overview of the evidence currently available from clinical trials and to discuss possible shortcomings and new strategies to be considered in future investigations.
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