Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study.
Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study.
复制标题
DOI：
10.1136/bmj-2022-072691
复制
发表时间：
2023-01-25
影响因子：
105.7
通讯作者：
Cummings, Jeffrey
中科院分区：
文献类型：
--
作者：
Jia, Jianping;Zhao, Tan;Liu, Zhaojun;Liang, Yumei;Li, Fangyu;Li, Yan;Liu, Wenying;Li, Fang;Shi, Shengliang;Zhou, Chunkui;Yang, Heyun;Liao, Zhengluan;Li, Yang;Zhao, Huiying;Zhang, Jintao;Zhang, Kunnan;Kan, Minchen;Yang, Shanshan;Li, Hao;Liu, Zhongling;Ma, Rong;Lv, Jihui;Wang, Yue;Yan, Xin;Liang, Furu;Yuan, Xiaoling;Zhang, Jinbiao;Gauthier, Serge;Cummings, Jeffrey
确定最佳的生活方式，以防止老年人的记忆丧失。基于人群的前瞻性队列研究。与会者来自中国北方、南方和西部的代表性地区。2009年基线时认知正常并接受载脂蛋白E（APOE）基因分型的60岁或以上个体。参与者被随访至死亡、停药或2019年12月26日。评估了6个健康生活方式因素：健康饮食（坚持12种合格食物中至少7种的推荐摄入量），定期体育锻炼（每周≥150分钟中等强度或≥75分钟剧烈强度），积极的社会接触（每周≥ 2次），积极的认知活动（每周≥ 2次），从不吸烟或既往吸烟，从不饮酒。如果参与者有四到六个健康的生活方式因素，则将其分为有利组，两到三个因素的平均组，以及零到一个因素的不利组。使用世界卫生组织/加州大学洛杉矶分校听觉语言学习测试评估记忆功能，并通过简易精神状态检查评估整体认知。线性混合模型被用来探讨生活方式因素对研究样本记忆的影响。共纳入29072例受试者（平均年龄72.23岁; 48.54%（n= 14113）为女性; 20.43%（n=5939）为APOE ε4携带者）。在10年的随访期间（2009-19），有利组的参与者比不利组的参与者记忆力下降更慢（0.028分/年，95%置信区间0.023至0.032，P<0.001）。具有良好生活方式（0.027，95%可信区间0.023 ~ 0.031）和平均生活方式（0.014，0.010 ~ 0.019）的APOE ε4携带者的记忆力下降比生活方式不良者慢。在非APOE ε4携带者中，与不利组相比，在有利组（0.029分/年，95%置信区间0.019至0.039）和平均组（0.019，0.011至0.027）的参与者中观察到相似的结果。APOE ε4状态和生活方式对记忆力下降没有显著的交互作用（P=0.52）。健康的生活方式与较慢的记忆衰退有关，即使存在APOE ε4等位基因。这项研究可能为保护老年人免受记忆力衰退提供重要信息。ClinicalTrials.gov NCT03653156。
To identify an optimal lifestyle profile to protect against memory loss in older individuals. Population based, prospective cohort study. Participants from areas representative of the north, south, and west of China. Individuals aged 60 years or older who had normal cognition and underwent apolipoprotein E (APOE) genotyping at baseline in 2009. Participants were followed up until death, discontinuation, or 26 December 2019. Six healthy lifestyle factors were assessed: a healthy diet (adherence to the recommended intake of at least 7 of 12 eligible food items), regular physical exercise (≥150 min of moderate intensity or ≥75 min of vigorous intensity, per week), active social contact (≥twice per week), active cognitive activity (≥twice per week), never or previously smoked, and never drinking alcohol. Participants were categorised into the favourable group if they had four to six healthy lifestyle factors, into the average group for two to three factors, and into the unfavourable group for zero to one factor. Memory function was assessed using the World Health Organization/University of California-Los Angeles Auditory Verbal Learning Test, and global cognition was assessed via the Mini-Mental State Examination. Linear mixed models were used to explore the impact of lifestyle factors on memory in the study sample. 29 072 participants were included (mean age of 72.23 years; 48.54% (n=14 113) were women; and 20.43% (n=5939) were APOE ε4 carriers). Over the 10 year follow-up period (2009-19), participants in the favourable group had slower memory decline than those in the unfavourable group (by 0.028 points/year, 95% confidence interval 0.023 to 0.032, P<0.001). APOE ε4 carriers with favourable (0.027, 95% confidence interval 0.023 to 0.031) and average (0.014, 0.010 to 0.019) lifestyles exhibited a slower memory decline than those with unfavourable lifestyles. Among people who were not carriers of APOE ε4, similar results were observed among participants in the favourable (0.029 points/year, 95% confidence interval 0.019 to 0.039) and average (0.019, 0.011 to 0.027) groups compared with those in the unfavourable group. APOE ε4 status and lifestyle profiles did not show a significant interaction effect on memory decline (P=0.52). A healthy lifestyle is associated with slower memory decline, even in the presence of the APOE ε4 allele. This study might offer important information to protect older adults against memory decline. ClinicalTrials.gov NCT03653156.
登录
查看更多内容
影响因子：
5.3
作者：
Choi D;Choi S;Park SM
通讯作者：
Park SM
影响因子：
9.9
作者：
Dhana, Klodian;Evans, Denis A.;Morris, Martha C.
通讯作者：
Morris, Martha C.
影响因子：
158.5
作者：
Hu, FB;Manson, JE;Willett, WC
通讯作者：
Willett, WC
影响因子：
6.6
作者：
Comijs, HC;Deeg, DJH;Jonker, C
通讯作者：
Jonker, C
影响因子：
5.1
作者：
Lee, Yunhwan;Kim, Jinhee;Back, Joung Hwan
通讯作者：
Back, Joung Hwan