Effect of smoking cessation on the risk of dementia: a longitudinal study.
Effect of smoking cessation on the risk of dementia: a longitudinal study.
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DOI：
10.1002/acn3.633
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发表时间：
2018-10
影响因子：
5.3
通讯作者：
Park SM
中科院分区：
文献类型：
--
作者：
Choi D;Choi S;Park SM
通过使用全国健康声明数据库来确定与戒烟时间有关的痴呆风险。该队列研究包括46140名年龄在60岁或以上的男性，他们来自韩国国民健康保险系统-国民健康筛查队列，这是一项2002年至2013年基于人群的国家健康筛查计划。在第一次（2002年和2003年）和第二次（2004年和2005年）健康检查期间的吸烟习惯变化问卷中，参与者被分为持续吸烟者，短期（少于4年）戒烟者，长期（4年或以上）戒烟者和从不吸烟者。从2006年1月1日起，研究人员对参与者进行了为期8年的随访，以了解他们是否出现了痴呆、阿尔茨海默病和血管性痴呆。与持续吸烟者相比，长期戒烟者和从不吸烟者总体痴呆风险降低（风险比，HR 0.86 95% CI，置信区间0.75-0.99和HR: 0.81； 95% CI分别为0.71-0.91）。与持续吸烟者相比，从不吸烟者阿尔茨海默病的风险降低（HR: 0.82; 95% CI: 0.70-0.96）。最后，与持续吸烟者相比，长期戒烟者（HR: 0.68; 95% CI: 0.48-0.96）和从不吸烟者（HR: 0.71; 95% CI: 0.54-0.95）患血管性痴呆的风险都降低了。吸烟会增加患痴呆症的风险。长期戒烟的吸烟者可能受益于患痴呆症的风险降低。因此，应该鼓励吸烟者戒烟，以减少患痴呆症的风险，特别是在已经有风险的老年人中。
To determine the risk of developing dementia in relation to duration of smoking cessation by using a nationwide health claims database. This cohort study included 46,140 men aged 60 years or older from Korean National Health Insurance System – National Health Screening Cohort, a population‐based national health screening program from 2002 to 2013. The changes in smoking habit from a questionnaire during the first (2002 and 2003) and second (2004 and 2005) health examination periods, participants were divided into continual smokers, short‐term (less than 4 years) quitters, long‐term (4 years or more) quitters, and never smokers. Participants were followed‐up for 8 years from January 1, 2006 for the development of overall dementia, Alzheimer's disease, and vascular dementia. Compared to continual smokers, long‐term quitters and never smokers had decreased risk of overall dementia (hazard ratio, HR 0.86 95% CI, confidence interval 0.75–0.99 and HR: 0.81; 95% CI: 0.71–0.91, respectively). Never smokers had decreased risk of Alzheimer's disease (HR: 0.82; 95% CI: 0.70–0.96) compared to continual smokers. Finally, both long‐term quitters (HR: 0.68; 95% CI: 0.48–0.96) and never smokers (HR: 0.71; 95% CI: 0.54–0.95) had decreased risk of vascular dementia compared to continual smokers. Smoking was associated with increased risk of dementia. Smokers who quit for a prolonged period of time may benefit from reduced risk of dementia. Therefore, smokers should be encouraged to quit in order to reduce the risk of developing dementia, especially in the elderly population who are already at risk.
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影响因子：
120.7
作者：
KANNEL, WB;WOLF, PA;DAGOSTINO, RB
通讯作者：
DAGOSTINO, RB
影响因子：
7.7
作者：
Lee, Juneyoung;Lee, Ji Sung;Kim, KeeWhan
通讯作者：
Kim, KeeWhan
影响因子：
8.3
作者：
Gorelick, PB
通讯作者：
Gorelick, PB
影响因子：
2.1
作者：
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通讯作者：
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影响因子：
6.1
作者：
ELROD, K;BUCCAFUSCO, JJ;JACKSON, WJ
通讯作者：
JACKSON, WJ