The μ opioid receptor is not involved in ethanol-stimulated dopamine release in the ventral striatum of C57BL/6J mice.
The μ opioid receptor is not involved in ethanol-stimulated dopamine release in the ventral striatum of C57BL/6J mice.
复制标题
μ 阿片受体不参与 C57BL/6J 小鼠腹侧纹状体乙醇刺激的多巴胺释放。
DOI：
10.1111/j.1530-0277.2010.01423.x
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Gonzales,RuebenA
中科院分区：
文献类型：
--
作者：
Ramachandra,Vorani;Kang,Francis;Kim,Christine;Nova,AlanS;Bajaj,Ankur;Hall,FScott;Uhl,GeorgeR;Gonzales,RuebenA
Background:The mu opioid receptor (MOR) has previously been found to regulate ethanol‐stimulated dopamine release under some, but not all, conditions. A difference in ethanol‐evoked dopamine release between male and female mixed background C57BL/6J‐129SvEv mice led to questions about its ubiquitous role in these effects of ethanol. Using congenic C57BL/6J MOR knockout (KO) mice and C57BL/6J mice pretreated with an irreversible MOR antagonist, we investigated the function of this receptor in ethanol‐stimulated dopamine release.Methods:Microdialysis was used to monitor dopamine release and ethanol clearance in MOR ‐/‐, +/+, and +/− . male and female mice after intraperitoneal (i.p.) injections of 1.0, 2.0, and 3.0 g/kg ethanol (or saline). We also measured the increase in dopamine release after 5 mg/kg morphine (i.p.) in male and female MOR+/+ and −/− mice. In a separate experiment, male C57BL/6J mice were pretreated with either the irreversible MOR antagonist beta funaltrexamine (BFNA) or vehicle, and dopamine levels were monitored after administration of 2 g/kg ethanol or 5 mg/kg morphine.Results:Although ethanol‐stimulated dopamine release at all the 3 doses of alcohol tested, there were no differences between MOR+/+, −/−, and +/− mice in these effects. Female mice had a more prolonged effect compared to males at the 1 g/kg dose. Administration of 2 g/kg ethanol also caused a similar increase in dopamine levels in both saline‐pretreated and BFNA‐pretreated mice. Five mg/kg morphine caused a significant increase in dopamine levels in MOR+/+ mice but not in MOR−/− mice and in saline‐pretreated mice but not in BFNA‐pretreated mice. Intraperitoneal saline injections had a significant, albeit small and transient, effect on dopamine release when given in a volume equivalent to the ethanol doses, but not in a volume equivalent to the 5 mg/kg morphine dose. Ethanol pharmacokinetics were similar in all genotypes and both sexes at each dose and in both pretreatment groups.Conclusions:MOR is not involved in ethanol‐stimulated dopamine release in the ventral striatum of C57BL/6J mice.
登录
查看更多内容
mu1-阿片受体可能参与芬太尼或吗啡诱导的脊髓上和脊柱部位的镇痛作用。
影响因子：
6.1
作者：
M. Narita;S. Imai;Yumiko Itou;Y. Yajima;Tsutomu Suzuki
通讯作者：
Tsutomu Suzuki
纳曲酮对 C57BL/6 小鼠乙醇奖励和歧视的影响。
DOI：
--
发表时间：
1999
期刊：
Alcoholism, clinical and experimental research.
影响因子：
--
作者：
Middaugh,LD;Kelley,BM;CuisonJr,ER;Groseclose,CH
通讯作者：
Groseclose,CH
影响因子：
5
作者：
S. Ward;D. Fries;D. L. Larson;P. Portoghese;A. Takemori
通讯作者：
S. Ward;D. Fries;D. L. Larson;P. Portoghese;A. Takemori
纳洛嗪和β-富纳曲明对 mu 1 和 mu 2 阿片类药物作用的拮抗作用的比较。
影响因子：
6.1
作者：
Pick,CG;Paul,D;Pasternak,GW
通讯作者：
Pasternak,GW
乙醇会增加 C57BL/6 小鼠腹侧纹状体的细胞外多巴胺浓度。
DOI：
10.1097/01.alc.0000075825.14331.65
发表时间：
2003
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Tang,Amanda;George,MagniaA;Randall,JudithA;Gonzales,RuebenA
通讯作者：
Gonzales,RuebenA