Suitability of aircraft wastewater for pathogen detection and public health surveillance.
Suitability of aircraft wastewater for pathogen detection and public health surveillance.
复制标题
DOI：
10.1016/j.scitotenv.2022.159162
复制
发表时间：
2023-01-15
影响因子：
9.8
通讯作者：
Farkas, Kata
中科院分区：
文献类型：
--
作者：
Jones, Davey L.;Rhymes, Jennifer M.;Wade, Matthew J.;Kevill, Jessica L.;Malham, Shelagh K.;Grimsley, Jasmine M. S.;Rimmer, Charlotte;Weightman, Andrew J.;Farkas, Kata
国际航空旅行现在被广泛认为是SARS-CoV-2跨国移动和全球传播的主要机制之一。监测从飞机和航空运输枢纽收集的人源性废水中的病毒载量和新谱系已被提议作为监测病毒病原体输入频率的有效方法。然而，这种方法的成功在很大程度上取决于航空乘客在旅途中的卫生间和排便习惯。在这项对英国成年人（n = 2103）的研究中，我们量化了在出发前、飞机上和抵达短途和长途航班时排便的可能性。然后，这些结果被用来评估在英国旅游中心捕获感染者信号的可能性。为了获得具有代表性的人口截面，调查按地理区域、性别、年龄、养育状况和社会阶层分层。我们发现，个人在短途航班（持续时间< 6小时）上排便的可能性较低（<总数的13%），但在长途航班上排便的可能性较高（<36%;持续时间> 6小时）。这种行为模式在男性和较年轻的年龄组中更常见。排便的最大可能性是在出发前（<39%）。根据已知的SARS-CoV-2粪便脱落率（30- 60%）以及受感染个体在短途（入境航班的71%）和长途航班（29%）上的相等概率，我们估计飞机废水可能会捕获约100%的细菌。8-14进入英国的SARS-CoV-2病例的%。蒙特卡洛模拟预测，在目前的大流行条件下，SARS-CoV-2将存在于14%的短途航班和62%的长途航班的废水中。我们的结论是，飞机废水本身是不足以有效地监测粪便传播的病原体的所有越境入境，但可以形成一个更广泛的战略，在国家边境的公共卫生监测的一部分。
International air travel is now widely recognised as one of the primary mechanisms responsible for the transnational movement and global spread of SARS-CoV-2. Monitoring the viral load and novel lineages within human-derived wastewater collected from aircraft and at air transport hubs has been proposed as an effective way to monitor the importation frequency of viral pathogens. The success of this approach, however, is highly dependent on the bathroom and defecation habits of air passengers during their journey. In this study of UK adults (n = 2103), we quantified the likelihood of defecation prior to departure, on the aircraft and upon arrival on both short- and long-haul flights. The results were then used to assess the likelihood of capturing the signal from infected individuals at UK travel hubs. To obtain a representative cross-section of the population, the survey was stratified by geographical region, gender, age, parenting status, and social class. We found that an individual's likelihood to defecate on short-haul flights (< 6 h in duration) was low (< 13 % of the total), but was higher on long-haul flights (< 36 %; > 6 h in duration). This behaviour pattern was higher among males and younger age groups. The maximum likelihood of defecation was prior to departure (< 39 %). Based on known SARS-CoV-2 faecal shedding rates (30–60 %) and an equal probability of infected individuals being on short- (71 % of inbound flights) and long-haul flights (29 %), we estimate that aircraft wastewater is likely to capture ca. 8–14 % of SARS-CoV-2 cases entering the UK. Monte Carlo simulations predicted that SARS-CoV-2 would be present in wastewater on 14 % of short-haul flights and 62 % of long-haul flights under current pandemic conditions. We conclude that aircraft wastewater alone is insufficient to effectively monitor all the transboundary entries of faecal-borne pathogens but can form part of a wider strategy for public heath surveillance at national borders.
登录
查看更多内容
影响因子：
11.8
作者：
Ahmed W;Bivins A;Simpson SL;Bertsch PM;Ehret J;Hosegood I;Metcalfe SS;Smith WJM;Thomas KV;Tynan J;Mueller JF
通讯作者：
Mueller JF
DOI：
10.1016/j.scitotenv.2022.153171
发表时间：
2022-05-10
期刊：
The Science of the total environment
影响因子：
--
作者：
Ahmed W;Bivins A;Smith WJM;Metcalfe S;Stephens M;Jennison AV;Moore FAJ;Bourke J;Schlebusch S;McMahon J;Hewitson G;Nguyen S;Barcelon J;Jackson G;Mueller JF;Ehret J;Hosegood I;Tian W;Wang H;Yang L;Bertsch PM;Tynan J;Thomas KV;Bibby K;Graber TE;Ziels R;Simpson SL
通讯作者：
Simpson SL
DOI：
10.1016/s2352-4642(22)00027-x
发表时间：
2022-05
期刊：
The Lancet. Child & adolescent health
影响因子：
--
作者：
Cloete J;Kruger A;Masha M;du Plessis NM;Mawela D;Tshukudu M;Manyane T;Komane L;Venter M;Jassat W;Goga A;Feucht U
通讯作者：
Feucht U
影响因子：
17.3
作者：
Aiyegbusi OL;Hughes SE;Turner G;Rivera SC;McMullan C;Chandan JS;Haroon S;Price G;Davies EH;Nirantharakumar K;Sapey E;Calvert MJ;TLC Study Group
通讯作者：
TLC Study Group
影响因子：
12.8
作者：
Hillary LS;Farkas K;Maher KH;Lucaci A;Thorpe J;Distaso MA;Gaze WH;Paterson S;Burke T;Connor TR;McDonald JE;Malham SK;Jones DL
通讯作者：
Jones DL