An interaction between carotene-15,15'-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone.
An interaction between carotene-15,15'-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone.
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DOI：
10.1002/ijc.26446
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发表时间：
2012-07-15
影响因子：
6.4
通讯作者：
Erdman, John W., Jr.
中科院分区：
文献类型：
--
作者：
Ford, Nikki A.;Moran, Nancy Engelmann;Smith, Joshua W.;Clinton, Steven K.;Erdman, John W., Jr.
番茄红素，番茄的红色色素，被假设可以降低前列腺癌的风险，前列腺癌是一种强烈依赖于睾丸激素的疾病。在这项研究中，缺乏胡萝卜素-15，15 '-单加氧酶（CMO-I-/-）表达的小鼠或野生型小鼠被喂食10%的番茄粉（TP），含番茄红素（248 nmol/g饮食）或其各自的对照饮食4天，之后测量血清睾酮。显著的饮食×基因型相互作用（P=0.02）表明TP降低了CMO-I−/−小鼠而不是野生型小鼠的血清睾酮浓度。同样，TP喂养的CMO-I−/−小鼠的睾丸睾酮水平降低（P=0.01），表明该组的睾酮合成可能受到抑制。番茄红素喂养的小鼠也观察到类似的模式。有趣的是，CMO-I−/−小鼠表现出编码CMO-II酶的基因的更高表达，该酶负责睾丸中的偏心氧化类胡萝卜素裂解。因此，我们推测，血清睾酮减少番茄红素代谢产物的氧化裂解的CMO-II在睾丸中。总的来说，这些研究结果表明，影响CMO-I表达及其与CMO-II相互作用的遗传多态性，加上饮食中番茄红素的变化，可能会调节睾酮的合成和血清浓度。此外，在遗传定义的小鼠模型中对番茄制品和番茄红素进行的仔细对照研究可能阐明可能影响前列腺癌风险的重要饮食×遗传相互作用。
Lycopene, the red pigment of tomatoes, is hypothesized to reduce prostate cancer risk, a disease strongly dependent upon testosterone. In this study, mice lacking the expression of carotene-15,15’-monooxygenase (CMO-I−/−) or wild-type mice were fed either a 10% tomato powder (TP), lycopene-containing (248 nmol/g diet), or their respective control diets for 4 days, after which serum testosterone was measured. A significant diet × genotype interaction (P=0.02) suggests that the TP reduces serum testosterone concentrations in CMO-I−/− mice but not in wild-type mice. Similarly, testicular testosterone was lowered in TP-fed CMO-I−/− mice (P=0.01), suggesting that testosterone synthesis may be inhibited in this group. A similar pattern was also observed for lycopene fed mice. Interestingly, the CMO-I−/− mice showed a greater expression of the gene encoding the CMO-II enzyme responsible for eccentric oxidative carotenoid cleavage in the testes. Therefore, we hypothesize that serum testosterone is reduced by lycopene metabolic products of oxidative cleavage by CMO-II in the testes. Overall, these findings suggest that genetic polymorphisms impacting CMO-I expression and its interaction with CMO-II, coupled with variations in dietary lycopene, may modulate testosterone synthesis and serum concentrations. Furthermore, carefully controlled studies with tomato products and lycopene in genetically defined murine models may elucidate important diet × genetic interactions that may impact prostate cancer risk.
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影响因子：
4.2
作者：
Ford, Nikki A.;Clinton, Steven K.;Erdman, John W., Jr.
通讯作者：
Erdman, John W., Jr.
影响因子：
2.9
作者：
Allen, CM;Schwartz, SJ;Clinton, SK
通讯作者：
Clinton, SK
影响因子：
6.2
作者：
Unger, JM;Thompson, IM;Coltman, CA
通讯作者：
Coltman, CA
影响因子：
4.8
作者：
Leung, W. C.;Hessel, S.;Lietz, G.
通讯作者：
Lietz, G.
影响因子：
3.9
作者：
Erdman, John W., Jr.;Ford, Nikki A.;Lindshield, Brian L.
通讯作者：
Lindshield, Brian L.