TFOS DEWS II Tear Film Report.

TFOS DEWS II Tear Film Report.
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DOI:
10.1016/j.jtos.2017.03.006
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发表时间:
2017-07
期刊:
The ocular surface
影响因子:
--
通讯作者:
Jones L
Jones L
中科院分区:
其他
文献类型:
--
作者:
Willcox MDP;Argüeso P;Georgiev GA;Holopainen JM;Laurie GW;Millar TJ;Papas EB;Rolland JP;Schmidt TA;Stahl U;Suarez T;Subbaraman LN;Uçakhan OÖ;Jones L

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泪膜小组委员会的成员回顾了泪膜在干眼病(DED)中的作用。小组委员会审查了泪液的生物物理和生物化学方面以及这些方面在DED中的变化。临床上,DED的特征在于泪液体积的损失、泪膜的更快速破裂和泪液从眼表面的蒸发增加。泪膜由多种物质组成,包括脂质、蛋白质、粘蛋白和电解质。所有这些都有助于泪膜的完整性,但它们如何相互作用仍然是一个活跃的研究领域。泪液膜渗透压增加DED。其他组分如蛋白质和粘蛋白的变化可用作DED的生物标志物。小组委员会建议未来的研究领域,以促进我们对泪膜的理解,以及它如何与DED一起变化。最后报告是在小组委员会所有成员和TFOS DEWS II全体成员审查后编写的。
The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research. Tear film osmolarity increases in DED. Changes to other components such as proteins and mucins can be used as biomarkers for DED. The Subcommittee recommended areas for future research to advance our understanding of the tear film and how this changes with DED. The final report was written after review by all Subcommittee members and the entire TFOS DEWS II membership.
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