A Prototype Wearable Device for Noninvasive Monitoring of Transcutaneous Oxygen
A Prototype Wearable Device for Noninvasive Monitoring of Transcutaneous Oxygen
复制标题
用于无创监测经皮氧气的原型可穿戴设备
DOI：
10.1109/tbcas.2023.3251321
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发表时间：
2023
影响因子：
5.1
通讯作者：
Guler, Ulkuhan
中科院分区：
文献类型：
--
作者：
Vakhter, Vladimir;Kahraman, Burak;Bu, Guixue;Foroozan, Foroohar;Guler, Ulkuhan
经皮氧监测是一种测量通过皮肤扩散的氧分压的无创方法，它与动脉中溶解氧的变化密切相关。发光氧传感是经皮氧检测技术之一。基于强度和寿命的测量是该技术中使用的两种众所周知的方法。后者更不受光路变化和反射的影响，使测量结果更不容易受到运动伪影和肤色变化的影响。尽管基于生命周期的方法很有前途，但在皮肤不受热的情况下，获取高分辨率生命周期数据对于准确测量人体经皮氧气至关重要。我们已经建立了一个紧凑的原型及其定制固件，用于经皮氧的寿命估计，并提供可穿戴设备。此外，我们对三名健康的人类志愿者进行了一项小型实验研究，以证明在不加热的情况下测量从皮肤扩散的氧气的概念。最后，该原型成功检测到由压力引起的动脉闭塞和缺氧气体输送引起的经皮氧分压变化所驱动的寿命值的变化。由于缺氧气体输送导致志愿者体内氧气压力的缓慢变化，该原型在一生中解决了1.34 ns的最小变化，对应于0.031 mmHg。该原型被认为是文献中第一个使用基于生命周期的技术在人类受试者中成功进行测量的原型。
Transcutaneous oxygen monitoring is a noninvasive method for measuring the partial pressure of oxygen diffusing through the skin, which strongly correlates with changes in dissolved oxygen in the arteries. Luminescent oxygen sensing is one of the techniques for assessing transcutaneous oxygen. Intensity- and lifetime-based measurements are two well-known methods used in this technique. The latter is more immune to optical path changes and reflections, making the measurements less vulnerable to motion artifacts and skin color changes. Although the lifetime-based method is promising, the acquisition of high-resolution lifetime data is crucial for accurate transcutaneous oxygen measurements from the human body when skin is not heated. We have built a compact prototype along with its custom firmware for the lifetime estimation of transcutaneous oxygen with a provision of a wearable device. Furthermore, we performed a small experiment study on three healthy human volunteers to prove the concept of measuring oxygen diffusing from the skin without heating. Lastly, the prototype successfully detected changes in lifetime values driven by the changes in transcutaneous oxygen partial pressure due to pressure-induced arterial occlusion and hypoxic gas delivery. The prototype resolved a minimum change of 1.34 ns in a lifetime that corresponds to 0.031 mmHg in response to slow changes in the oxygen pressure in the volunteer's body caused by hypoxic gas delivery. The prototype is believed to be the first in the literature to successfully conduct measurements in human subjects using the lifetime-based technique.
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DOI：
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影响因子：
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DOI：
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发表时间：
2022
期刊：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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