A longitudinal study on early hospitalized airway infections and subsequent childhood asthma.
A longitudinal study on early hospitalized airway infections and subsequent childhood asthma.
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DOI：
10.1371/journal.pone.0121906
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Soong WJ
中科院分区：
文献类型：
--
作者：
Jeng MJ;Lee YS;Tsao PC;Yang CF;Soong WJ
急性气道感染，包括细支气管炎，是幼儿住院的常见原因。后期哮喘的发生可能与幼儿早期气道感染有关。本研究旨在调查幼儿（< 3 岁）住院气道感染 (HAI) 与儿童后期哮喘之间的关系。从台湾国民健康保险研究数据库中检索1997-2000年患有细支气管炎或其他急性气道感染（其他HAI组）的住院儿童（<3岁），并与年龄和性别匹配的受试者进行比较，直至10岁；以及潜在的合并症和医疗保健条件。总共有 3,264 名儿童（1,981 名患有细支气管炎；1,283 名患有其他 HAI）与 18,527 名对照儿童进行了比较。研究组儿童哮喘的发病率（16.2%）高于对照组（11.7%），大多数病例在3-5岁之间诊断。与对照组相比，细支气管炎亚组和其他 HAI 亚组的风险比分别为 1.583 (95% CI: 1.414-1.772) 和 1.226 (95% CI: 1.053-1.428)，与对照组相比，细支气管炎亚组的风险比为 1.228 (95% CI: 1.075-1.542)。其他 HAI 子组。与对照组相比，细支气管炎亚组先天性心脏病（CHD）儿童在 3-5 岁时的比值比显着较高（1.973，95% CI：1.193-3.263）。因急性 HAI 住院的幼儿（< 3 岁）在 3 至 10 岁时患儿童哮喘的风险较高。应告知 0 至 2 岁患有 HAI 的儿童的父母，儿童患哮喘的风险较高，尤其是患有先心病和细支气管炎的儿童。
Acute airway infections, including bronchiolitis, are common causes of early childhood hospitalization. The development of later asthma may be related to early airway infections in young children. This study is to investigate the relationship between hospitalized airway infections (HAI) in young children (< 3 years old) and later childhood asthma. Hospitalized children (< 3 years old) with bronchiolitis or other acute airway infections (other HAI group) from 1997-2000 were retrieved from the National Health Insurance Research Database of Taiwan, and compared to age- and gender-matched subjects with regards to asthma until 10 years of age; and potential comorbidities and medical care conditions. In total, 3,264 children (1,981 with bronchiolitis; 1,283 with other HAIs) were compared to 18,527 controls. The incidence of childhood asthma was higher in the study (16.2%) than the control (11.7%) group, and most cases were diagnosed between 3-5 years old. The hazard ratios were 1.583 (95% CI: 1.414-1.772) and 1.226 (95% CI: 1.053-1.428) for the bronchiolitis and other HAI subgroups, respectively, compared to the control group, and 1.228 (95% CI: 1.075-1.542) in the bronchiolitis subgroup compared to the other HAIs subgroup. A significantly higher odds ratio (1.973, 95% CI: 1.193-3.263) for the children with congenital heart disease (CHD) in the bronchiolitis subgroup was found at an age of 3-5 years compared to the control group. Young children (< 3 years old) hospitalized due to acute HAIs are at a higher risk of developing childhood asthma at age 3 to 10 years. The parents of children with HAIs at age 0 to 2 years should be informed for the higher risk of developing childhood asthma, especially in children with CHD and bronchiolitis.
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影响因子：
2.2
作者：
Chen, Ta-Cheng;Chen, Yen-Yu;Lai, Chien-Hsu
通讯作者：
Lai, Chien-Hsu
影响因子：
2.6
作者：
Chen, CY;Chiu, HF;Yang, CY
通讯作者：
Yang, CY
在挪威阿克斯胡斯县，婴儿期急性细支气管炎是喘息的危险因素，导致肺功能下降七年。
影响因子：
2.4
作者：
Fjaerli, Hans-Olav;Farstad, Teresa;Rod, Gisle;Ufert, Gunn Kristin;Gulbrandsen, Pal;Nakstad, Britt
通讯作者：
Nakstad, Britt
影响因子：
8
作者：
Carroll, Kecia N.;Gebretsadik, Tebeb;Hartert, Tina V.
通讯作者：
Hartert, Tina V.
影响因子：
4.4
作者：
Henderson, J;Hilliard, TN;Thomas, HM
通讯作者：
Thomas, HM