MHC class II in renal tubules plays an essential role in renal fibrosis
MHC class II in renal tubules plays an essential role in renal fibrosis
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肾小管中的 MHC II 类在肾纤维化中发挥重要作用
DOI：
10.1038/s41423-021-00763-z
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发表时间：
2021-09
影响因子：
24.1
通讯作者：
Tuo Deng
中科院分区：
文献类型：
--
作者：
Yunfeng Zhou;Zhaokang Luo;Chenghui Liao;Rong Cao;Zain Hussain;Jie Wang;Yeting Zhou;Tie Chen;Jie Sun;Zhong Huang;Baohua Liu;Xiaoyan Zhang;Youfei Guan;Tuo Deng
Immunomodulation is considered a potential therapeutic approach for chronic kidney disease (CKD). Although it has been previously reported that CD4+T cells contribute to the development of renal fibrosis, the role of MHC class II (MHCII) in the development of renal fibrosis remains largely unknown. The present study reports that the expression of MHCII molecules in renal cortical tubules is upregulated in mouse renal fibrosis models generated by unilateral ureter obstruction (UUO) and folic acid (FA). Proximal tubule epithelial cells (PTECs) are functional antigen-presenting cells that promote the proliferation of CD4+T cells in an MHCII-dependent manner. PTECs from mice with renal fibrosis had a stronger ability to induce T cell proliferation and cytokine production than control cells. Global or renal tubule-specific ablation of H2-Ab1 significantly alleviated renal fibrosis following UUO or FA treatment. Renal expression of profibrotic genes showed a consistent reduction in H2-Ab1 gene-deficient mouse lines. Moreover, there was a marked increase in renal tissue CD4+T cells after UUO or FA treatment and a significant decrease following renal tubule-specific ablation of H2-Ab1. Furthermore, renal tubule-specific H2-Ab1 gene knockout mice exhibited higher proportions of regulatory T cells (Tregs) and lower proportions of Th2 cells in the UUO- or FA-treated kidneys. Finally, Immunohistochemistry (IHC) studies showed increased renal expression of MHCII and the profibrotic gene α smooth muscle actin (α-SMA) in CKD patients. Together, our human and mouse data demonstrate that renal tubular MHCII plays an important role in the pathogenesis of renal fibrosis.
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影响因子：
16.6
作者：
Deng T;Liu J;Deng Y;Minze L;Xiao X;Wright V;Yu R;Li XC;Blaszczak A;Bergin S;DiSilvestro D;Judd R;Bradley D;Caligiuri M;Lyon CJ;Hsueh WA
通讯作者：
Hsueh WA
影响因子：
2.5
作者：
Bikbov, Boris;Perico, Norberto;Remuzzi, Giuseppe
通讯作者：
Remuzzi, Giuseppe
DOI：
10.1016/j.bbadis.2020.165996
发表时间：
2021-01-23
影响因子：
6.2
作者：
Luan, Zhilin;Wei, Yuanyi;Zhang, Xiaoyan
通讯作者：
Zhang, Xiaoyan
DOI：
10.1152/ajprenal.00102.2014
发表时间：
2014-08
期刊：
American journal of physiology. Renal physiology
影响因子：
--
作者：
Jinhua Tang;Yanli Yan;T. Zhao;R. Gong;G. Bayliss;Haidong Yan;S. Zhuang
通讯作者：
Jinhua Tang;Yanli Yan;T. Zhao;R. Gong;G. Bayliss;Haidong Yan;S. Zhuang
影响因子：
168.9
作者：
Jha, Vivekanand;Garcia-Garcia, Guillermo;Yang, Chih-Wei
通讯作者：
Yang, Chih-Wei