Structural pathology underlying neuroendocrine dysfunction in schizophrenia.
Structural pathology underlying neuroendocrine dysfunction in schizophrenia.
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DOI：
10.1016/j.bbr.2010.11.025
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发表时间：
2011-03-17
影响因子：
2.7
通讯作者：
Torres, Ivan
中科院分区：
文献类型：
--
作者：
Goldman, Morris B.;Wang, Lei;Wachi, Carly;Daudi, Sheeraz;Csernansky, John;Marlow-O'Connor, Megan;Keedy, Sarah;Torres, Ivan
多饮性低钠血症性精神分裂症（PHS）患者表现出神经内分泌活动的改变，这与他们危及生命的水失衡以及前海马功能受损和体积减少有关。无低钠血症的多饮性精神分裂症患者（多饮性正常单钠性精神分裂症：PNS）在神经内分泌活动和海马前部功能方面表现出类似的变化，尽管不那么明显，但海马前部体积没有减少。事实上，在水平衡正常的患者（非多饮正常型精神分裂症：NNS）中，其神经内分泌活动和海马前部功能明显不同于多饮患者，海马前部体积减少。为了验证这些发现，我们测量了26名精神分裂症患者（10名PNS， 7名PHS， 9名NNS）和12名年龄和性别匹配的健康对照者的海马、杏仁核和第三脑室形状。双侧向内变形局限于小灵通的海马前外侧表面（调节神经内分泌对心理刺激反应的神经回路的一部分），PNS的程度较小，而NNS的变形局限于内侧表面。右侧内侧杏仁核是该神经回路的关键部分，在两组中均可见相应的变形，并与靠近神经内分泌核的第三脑室的体积相关。最后，这些结构发现在海马介导的应激反应受损的患者中最为明显。这些结果调和了先前相互矛盾的数据，并支持了海马体前外侧病理破坏伴或不伴低钠血症的多饮患者的神经内分泌功能的观点。这些发现与潜在的精神疾病之间的关系仍有待确定。
Polydipsic hyponatremic schizophrenic (PHS) patients exhibit altered neuroendocrine activity that has been linked to their life-threatening water imbalance, as well as to impaired function and reduced volume of the anterior hippocampus. Polydipsic patients without hyponatremia (polydipsic normonatremic schizophrenics: PNS) exhibit similar, albeit less marked, changes in neuroendocrine activity and anterior hippocampal function, but not reduced anterior hippocampal volume. Indeed, reduced anterior hippocampal volume is seen in patients with normal water balance (nonpolydipsic normonatremic schizophrenics: NNS) whose neuroendocrine activity and anterior hippocampal function differ markedly from those with polydipsia. In an effort to reconcile these findings we measured hippocampal, amygdala and 3rd ventricle shapes in 26 schizophrenic patients (10 PNS, 7 PHS, 9 NNS) and 12 healthy controls matched for age and gender. Bilateral inward deformations were localized to the anterior lateral hippocampal surface (part of a neurocircuit which modulates neuroendocrine responses to psychological stimuli) in PHS and to a lesser extent in PNS, while deformations in NNS were restricted to the medial surface. Proportional deformations of the right medial amygdala, a key segment of this neurocircuit, were seen in both polydipsic groups, and correlated with the volume of the 3rd ventricle, which lies adjacent to the neuroendocrine nuclei. Finally, these structural findings were most marked in those with impaired hippocampal-mediated stress responses. These results reconcile previously conflicting data, and support the view that anterior lateral hippocampal pathology disrupts neuroendocrine function in polydipsic patients with and without hyponatremia. The relationship of these findings to the underlying mental illness remains to be established.
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DOI：
10.1023/b:visi.0000043755.93987.aa
发表时间：
2005-02-01
影响因子：
19.5
作者：
Beg, MF;Miller, MI;Younes, L
通讯作者：
Younes, L
影响因子：
5.7
作者：
Csernansky, JG;Wang, L;Miller, MI
通讯作者：
Miller, MI
DOI：
10.1038/npp.2009.111
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.8
作者：
Goldman, Morris B.;Wood, Gordon;Pilla, Ramani S.
通讯作者：
Pilla, Ramani S.
影响因子：
10.6
作者：
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通讯作者：
Tsuang, Ming T.