Magnetic nanoparticles for targeted therapeutic gene delivery and magnetic-inducing heating on hepatoma
Magnetic nanoparticles for targeted therapeutic gene delivery and magnetic-inducing heating on hepatoma
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用于肝癌靶向治疗基因传递和磁诱导加热的磁性纳米颗粒
DOI：
10.1088/0957-4484/25/34/345101
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发表时间：
2014-08
期刊：
影响因子：
3.5
通讯作者：
Zhang, Dongsheng
中科院分区：
文献类型：
--
作者：
Li, Hongbo;Zhang, Hao;Wang, Ling;Zhang, Dongsheng
基因治疗在治疗癌症方面有很大的前景，但由于不受控制的基因传递和表达，其临床应用受到阻碍。为了开发一种靶向、安全、高效的肿瘤治疗系统，我们以磁性纳米颗粒(MNPs)为载体，构建了组织特异性自杀基因传递系统，用于肝癌的基因治疗和热疗。自杀基因具有肝癌靶向性和低氧增强性，MNPs具有将温度提高到交变磁场(AMF)作用下肿瘤热疗的有效范围的能力。在体内外评价靶向基因治疗联合热疗对肿瘤的杀伤作用。实验证明，热疗联合靶向基因治疗系统为肿瘤治疗提供了一种有效的工具，具有高选择性和协同抑制肝癌的作用。
Gene therapy holds great promise for treating cancers, but their clinical applications are being hampered due to uncontrolled gene delivery and expression. To develop a targeted, safe and efficient tumor therapy system, we constructed a tissue-specific suicide gene delivery system by using magnetic nanoparticles (MNPs) as carriers for the combination of gene therapy and hyperthermia on hepatoma. The suicide gene was hepatoma-targeted and hypoxia-enhanced, and the MNPs possessed the ability to elevate temperature to the effective range for tumor hyperthermia as imposed on an alternating magnetic field (AMF). The tumoricidal effects of targeted gene therapy associated with hyperthermia were evaluated in vitro and in vivo. The experiment demonstrated that hyperthermia combined with a targeted gene therapy system proffer an effective tool for tumor therapy with high selectivity and the synergistic effect of hepatoma suppression.
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DOI：
10.1016/j.jconrel.2013.06.033
发表时间：
2013-10-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Kim HA;Nam K;Lee M;Kim SW
通讯作者：
Kim SW
影响因子：
2.7
作者：
Zhang HY;Liu R;Xing YJ;Xu P;Li Y;Li CJ
通讯作者：
Li CJ
影响因子：
9.7
作者：
Ju Hui Park;K. Kim;Y. Lee;T. Lee;KyeongMin Kim;Sang-Soep Nahm;Young-Seo Park;G. Cheon;S. Lim;J. Kang
通讯作者：
Ju Hui Park;K. Kim;Y. Lee;T. Lee;KyeongMin Kim;Sang-Soep Nahm;Young-Seo Park;G. Cheon;S. Lim;J. Kang
影响因子：
--
作者：
C. Smerdou;S. Menne;R. Hernández-Alcoceba;G. González-Aseguinolaza
通讯作者：
C. Smerdou;S. Menne;R. Hernández-Alcoceba;G. González-Aseguinolaza
影响因子：
3.7
作者：
Utting, J. C.;Robins, S. P.;Arnett, T. R.
通讯作者：
Arnett, T. R.