Noise in biology.

Noise in biology.
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DOI:
10.1088/0034-4885/77/2/026601
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发表时间:
2014
期刊:
Reports on progress in physics. Physical Society (Great Britain)
影响因子:
--
通讯作者:
Tsimring LS
Tsimring LS
中科院分区:
其他
文献类型:
--
作者:
Tsimring LS

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噪音渗透到生物学的各个层面,从最基本的分子、亚细胞过程到组织、器官、生物体和种群的动态。噪音在生物过程中的功能作用可能有很大差异。沿着产生随机突变、使同基因群体的表型多样化、限制信号传递的信息容量等标准的、增加熵的作用,它有时通过加速进化的步伐、在动态环境中提供选择优势、增强生物分子的细胞内转运和增加信号通路的信息容量而发挥更令人惊讶的建设性作用。这篇简短的评论涵盖了最近在理解不同尺度的生物系统中的波动机制和影响以及数学建模的基本方法方面的进展。
Noise permeates biology on all levels, from the most basic molecular, sub-cellular processes to the dynamics of tissues, organs, organisms, and populations. The functional roles of noise in biological processes can vary greatly. Along with standard, entropy-increasing effects of producing random mutations, diversifying phenotypes in isogenic populations, limiting information capacity of signaling relays, it occasionally plays more surprising constructive roles by accelerating the pace of evolution, providing selective advantage in dynamic environments, enhancing intracellular transport of biomolecules and increasing information capacity of signaling pathways. This short review covers the recent progress in understanding mechanisms and effects of fluctuations in biological systems of different scales and the basic approaches to their mathematical modeling.
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