Expert Review of Non-Hodgkin’s Lymphomas in a Population-Based Cancer Registry
Expert Review of Non-Hodgkin’s Lymphomas in a Population-Based Cancer Registry
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基于人群的癌症登记中非霍奇金淋巴瘤的专家审查
DOI：
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
E. Holly
中科院分区：
文献类型：
--
作者：
C. Clarke;S. Glaser;R. Dorfman;P. Bracci;E. Eberle;E. Holly
近几十年来，非霍奇金淋巴瘤（NHL）的发病率几乎翻了一番。要了解这些趋势背后的原因，需要利用癌症登记或其他多中心数据对大量人群的 NHL 亚型进行详细监测和流行病学研究。然而，尽管对发病率统计和研究的准确性有影响，但人们对此类数据中 NHL 诊断和亚型分类的可靠性知之甚少。对向大湾区癌症登记处报告并参与大型人群病例对照研究的 1526 名 NHL 患者完成了专家病理复审。通过阳性预测值和 κ 统计来衡量登记诊断与专家诊断以及国际肿瘤疾病分类 2（工作配方）亚型分类的一致性。登记和专家诊断的一致性很高（98%）。复查时发现 30 名患者没有患有 NHL；其中大多数患有白血病。对于亚型，登记处和专家分类的一致性较为温和（59%）。不同亚型的一致性差异很大，从 5% 到 100% 不等，最常见的亚型弥漫性大细胞淋巴瘤的一致性为 77%。 128 例登记未分类的淋巴瘤中，77% 在重新审查时被指定为亚型。我们的分析表明，癌症登记数据信息中 NHL 的诊断可靠性极好，但亚型可靠性较差，这对于解释淋巴瘤时间趋势至关重要。因此，20 世纪 90 年代初的 NHL 总体发病率和生存统计数据可能是准确的，但亚型特异性统计数据可能存在很大偏差，特别是因为未分类淋巴瘤的比例很高（15-20%）。
Incidence rates of non-Hodgkin’s lymphomas (NHLs) have nearly doubled in recent decades. Understanding the reasons behind these trends will require detailed surveillance and epidemiological study of NHL subtypes in large populations, using cancer registry or other multicenter data. However, little is known regarding the reliability of NHL diagnosis and subtype classification in such data, despite implications for the accuracy of incidence statistics and studies. Expert pathological re-review was completed for 1526 NHL patients who were reported to the Greater Bay Area Cancer Registry and who participated in a large population-based case-control study. Agreement of registry diagnosis with expert diagnosis and with International Classification of Diseases for Oncology-2 (Working Formulation) subtype classifications was measured with positive predictive values and κ statistics. Agreement of registry and expert diagnoses was high (98%). Thirty patients were found on review not to have NHL; most of these had leukemia. For subtypes, agreement of registry and expert classification was more moderate (59%). Agreement varied substantially by subtype from 5% to 100% and was 77% for the most common subtype, diffuse large cell lymphoma. Seventy-seven percent of 128 registry-unclassified lymphomas were assigned a subtype on re-review. Our analyses suggest excellent diagnostic reliability but poorer subtype reliability of NHL in cancer registry data information that is critical to the interpretation of lymphoma time trends. Thus, overall NHL incidence and survival statistics from the early 1990s are probably accurate, but subtype-specific statistics could be substantially biased, especially because of high (15–20%) proportions of unclassified lymphomas.
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影响因子：
5.6
作者：
Holly,ElizabethA;Gautam,Manjushree;Bracci,PaigeM
通讯作者：
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影响因子：
12.7
作者：
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通讯作者：
Bracci,PM
影响因子：
5
作者：
Holly, EA;Lele, C;McGrath, MS
通讯作者：
McGrath, MS
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DOI：
10.1097/00042560-199707010-00006
发表时间：
1997
期刊：
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
影响因子：
--
作者：
Holly,EA;Lele,C;Bracci,P
通讯作者：
Bracci,P
影响因子：
5
作者：
Holly, EA;Eberle, CA;Bracci, PM
通讯作者：
Bracci, PM