Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila
Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila
复制标题
最近的重复导致 12 种果蝇胰蛋白酶基因快速多样化
DOI:
10.1007/s10709-012-9682-5
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发表时间:
2012-09
期刊:
影响因子:
--
通讯作者:
Shengjun Tan
中科院分区:
文献类型:
--
作者:
Luolan Li;Shabana Memon;Yuanchu Fan;Sihai Yang;Shengjun Tan
Trypsin participates in many fundamental biological processes, the most notably in digesting food. The 12 species of Drosophila provide a great opportunity to analyze the duplication pattern of trypsins and their association with dietary changes. Here, we find that the trypsin family expands dramatically after speciation. The duplication events are strongly related to the host preferences, with significantly more copy numbers in species breeding on rotting fruits. Temporal analysis of the duplication events indicates that the occurrences of these events are not simultaneous, but rather correlate to the ecological change or host shift. Furthermore, we find that the specialists and generalists have different adaptive selections, which is revealed by dynamic duplication and/or deletion and relatively high Ka/Ks values on the duplicated events in specialists. Our findings suggest that the duplication of trypsin genes has played an important role in the adaption of Drosophila to the diverse ecosystems.
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