Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila

Recent duplications drive rapid diversification of trypsin genes in 12 Drosophila
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最近的重复导致 12 种果蝇胰蛋白酶基因快速多样化

DOI:
10.1007/s10709-012-9682-5
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发表时间:
2012-09
期刊:
Genetica: the International Journal On Genetics
影响因子:
--
通讯作者:
Shengjun Tan
Shengjun Tan
中科院分区:
其他
文献类型:
--
作者:
Luolan Li;Shabana Memon;Yuanchu Fan;Sihai Yang;Shengjun Tan

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胰蛋白酶参与许多基本的生物过程,最显着的是消化食物。 12 种果蝇为分析胰蛋白酶的复制模式及其与饮食变化的关系提供了绝佳的机会。在这里,我们发现胰蛋白酶家族在物种形成后急剧扩张。复制事件与宿主偏好密切相关,在腐烂水果上繁殖的物种的拷贝数显着增加。对重复事件的时间分析表明,这些事件的发生不是同时发生的,而是与生态变化或宿主转移相关。此外,我们发现专家和通才具有不同的适应性选择,这通过专家的重复事件的动态复制和/或删除以及相对较高的 Ka/Ks 值来揭示。我们的研究结果表明,胰蛋白酶基因的重复在果蝇适应多样化生态系统中发挥了重要作用。
Trypsin participates in many fundamental biological processes, the most notably in digesting food. The 12 species of Drosophila provide a great opportunity to analyze the duplication pattern of trypsins and their association with dietary changes. Here, we find that the trypsin family expands dramatically after speciation. The duplication events are strongly related to the host preferences, with significantly more copy numbers in species breeding on rotting fruits. Temporal analysis of the duplication events indicates that the occurrences of these events are not simultaneous, but rather correlate to the ecological change or host shift. Furthermore, we find that the specialists and generalists have different adaptive selections, which is revealed by dynamic duplication and/or deletion and relatively high Ka/Ks values on the duplicated events in specialists. Our findings suggest that the duplication of trypsin genes has played an important role in the adaption of Drosophila to the diverse ecosystems.
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