Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.
Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.
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DOI：
10.1016/j.pestbp.2013.02.007
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发表时间：
2013-07-01
影响因子：
4.7
通讯作者：
Dong, Ke
中科院分区：
文献类型：
--
作者：
Rinkevich, Frank D.;Du, Yuzhe;Dong, Ke
拟除虫菊酯杀虫剂针对电压门控钠通道，这对神经系统的电信号传导至关重要。拟除虫菊酯在控制节肢动物害虫和病媒方面的大量使用导致了全球范围内许多拟除虫菊酯耐药性的实例。在过去的二十年中，研究已经发现了大量与拟除虫菊酯耐药性相关的钠通道突变。本综述的目的是总结在对农业或人类健康具有重要意义的节肢动物害虫中已发现的常见和独特的钠通道突变。这些突变的鉴定为现场耐药性监测提供了有价值的分子标记，并有助于发现钠通道上难以捉摸的拟除虫菊酯受体位点。
Pyrethroid insecticides target voltage-gated sodium channels, which are critical for electrical signaling in the nervous system. The intensive use of pyrethroids in controlling arthropod pests and disease vectors has led to many instances of pyrethroid resistance around the globe. In the past two decades, studies have identified a large number of sodium channel mutations that are associated with resistance to pyrethroids. The purpose of this review is to summarize both common and unique sodium channel mutations that have been identified in arthropod pests of importance to agriculture or human health. Identification of these mutations provides valuable molecular markers for resistance monitoring in the field and helped the discovery of the elusive pyrethroid receptor site(s) on the sodium channel.
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影响因子：
3.7
作者：
Chen L;Zhong D;Zhang D;Shi L;Zhou G;Gong M;Zhou H;Sun Y;Ma L;He J;Hong S;Zhou D;Xiong C;Chen C;Zou P;Zhu C;Yan G
通讯作者：
Yan G
影响因子：
3.8
作者：
Burton, Mark J.;Mellor, Ian R.;Williamson, Martin S.
通讯作者：
Williamson, Martin S.
影响因子：
1.9
作者：
Brengues, C;Hawkes, NJ;Hemingway, J
通讯作者：
Hemingway, J
影响因子：
4.1
作者：
Du, Yuzhe;Lee, Jung-Eun;Dong, Ke
通讯作者：
Dong, Ke
影响因子：
1.3
作者：
Bao, Wen Xue;Sonoda, Shoji
通讯作者：
Sonoda, Shoji