Oral lichen planus is a unique disease model for studying chronic inflammation and oral cancer.
Oral lichen planus is a unique disease model for studying chronic inflammation and oral cancer.
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DOI：
10.1016/j.mehy.2010.07.002
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发表时间：
2010-12
影响因子：
4.7
通讯作者：
Hu, Shen
中科院分区：
文献类型：
--
作者：
Liu, Yi;Messadi, Diana V.;Wu, Hongkun;Hu, Shen
口腔扁平苔藓（OLP）是一种慢性炎症性疾病，世界卫生组织将其定义为潜在的癌前病变，代表与口腔癌风险显着增加相关的普遍状态。我们提出一个假设，即浸润性T淋巴细胞释放的细胞因子和趋化因子等炎症介质诱导口腔上皮细胞蛋白质发生根本性变化，导致OLP进展为口腔鳞状细胞癌（OSCC）。这些改变的蛋白质可以作为与局部微环境和 OSCC 发展相关的关键危险因素。这些蛋白质的鉴定将有助于我们了解慢性炎症与口腔鳞癌之间的联系。
Oral lichen planus (OLP) is a chronic inflammatory disease, which has been defined by the World Health Organization as a potential precancerous condition, representing a generalized state associated with a significantly increased risk of oral cancer. We would like to put forward a hypothesis that inflammatory mediators such as cytokines and chemokines released from infiltrating T lymphocytes induce fundamental changes of proteins in oral epithelial cells, leading to the progression of OLP to oral squamous cell carcinoma (OSCC). These altered proteins can act as the key risk factors associated with the local microenvironment and development of OSCC. Identification of these proteins would add to our understanding of the connection between chronic inflammation and OSCC.
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影响因子：
3.4
作者：
Ahram, M;Flaig, MJ;Emmert-Buck, MR
通讯作者：
Emmert-Buck, MR
影响因子：
3.3
作者：
Ebrahimi, M;Wahlin, YB;Nylander, K
通讯作者：
Nylander, K
影响因子：
3
作者：
Bascones, C;Gonzalez-Moles, MA;Bascones, A
通讯作者：
Bascones, A
DOI：
10.1016/s1079-2104(99)70116-2
发表时间：
1999-08-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Bloor, BK;Malik, FK;Morgan, PR
通讯作者：
Morgan, PR
影响因子：
12.3
作者：
Fermin, Damian;Allen, Baxter B.;Blackwell, Thomas W.;Menon, Rajasree;Adamski, Marcin;Xu, Yin;Ulintz, Peter;Omenn, Gilbert S.;States, David J.
通讯作者：
States, David J.