Emerging Biopharmaceuticals from Pimpinella Genus.

Emerging Biopharmaceuticals from Pimpinella Genus.
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DOI:
10.3390/molecules28041571
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发表时间:
2023-02-06
期刊:
影响因子:
4.6
通讯作者:
Jin, Hui-Zi
Jin, Hui-Zi
中科院分区:
化学2区
文献类型:
--
作者:
Wu, Jiajia;Cao, Zhen;Hassan, Syed Shams ul;Zhang, Haozhen;Ishaq, Muhammad;Yu, Xu;Yan, Shikai;Xiao, Xue;Jin, Hui-Zi

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植物衍生的天然产物经过多年的进化,编码了生物测定,仍然是药物的第一个曙光。大多数研究人员都专注于从常用的茴芹属物种,如P. anisum,P. thellungiana,P.虎耳草和P. brachycarpa中提取的天然化合物,以研究其抗氧化,抗菌和抗炎特性。民族药理学研究表明,茴芹属植物具有药食同源的特性,主要用于治疗胃肠功能障碍、呼吸系统疾病、驱虫、利尿等。茴芹属植物天然产物的研究。揭示了含有苯丙素类、萜类、类黄酮、香豆素、甾醇和有机酸的许多天然产物。这些天然产物有可能提供未来的药物来治疗关键疾病,如癌症,高血压,微生物和昆虫感染以及严重炎症。从茴芹属植物中分离和开发新的化合物及其药理临床应用价值是一个新的研究领域。本文综述了茴芹属25种植物的传统应用、植物化学和药理学研究进展。
Evolved over eons to encode biological assays, plants-derived natural products are still the first dawn of drugs. Most researchers have focused on natural compounds derived from commonly used Pimpinella species, such as P. anisum, P. thellungiana, P. saxifrage, and P. brachycarpa, to investigate their antioxidant, antibacterial, and anti-inflammatory properties. Ethnopharmacological studies demonstrated that the genus Pimpinella has the homology characteristics of medicine and food and mainly in the therapy of gastrointestinal dysfunction, respiratory diseases, deworming, and diuresis. The natural product investigation of Pimpinella spp. revealed numerous natural products containing phenylpropanoids, terpenoids, flavonoids, coumarins, sterols, and organic acids. These natural products have the potential to provide future drugs against crucial diseases, such as cancer, hypertension, microbial and insectile infections, and severe inflammations. It is an upcoming field of research to probe a novel and pharmaceutically clinical value on compounds from the genus Pimpinella. In this review, we attempt to summarize the present knowledge on the traditional applications, phytochemistry, and pharmacology of more than twenty-five species of the genus Pimpinella.
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